A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

Conclusions
Among Europeans, TCA interactions with variants in BRE and UBE2E2 were identified in relation to RR intervals. Among Hispanic/Latinos, variants in TGFBR3 modified the relation between TCAs and QT intervals. Future studies are required to confirm our results.

Source: Journal of Medical Genetics - April 24, 2017 Category: Genetics & Stem Cells Authors: Noordam, R., Sitlani, C. M., Avery, C. L., Stewart, J. D., Gogarten, S. M., Wiggins, K. L., Trompet, S., Warren, H. R., Sun, F., Evans, D. S., Li, X., Li, J., Smith, A. V., Bis, J. C., Brody, J. A., Busch, E. L., Caulfield, M. J., Chen, Y.-D. I., Cummings Tags: Editor's choice Complex traits Source Type: research