Effects of an EP2 and EP3 Receptor Dual Agonist, ONO ‐8055, on a Radical Hysterectomy‐Induced Underactive Bladder Model in Monkeys

ConclusionsWe developed a neurogenic UAB model in primates. As ONO‐8055 improved voiding function in this model to at least the same degree as DIS, this EP2 and EP3 receptor dual agonist has the potential to be a candidate for neurogenic UAB pharmacotherapy.

Source: LUTS: Lower Urinary Tract Symptoms - April 25, 2017 Category: Urology & Nephrology Authors: Hidekazu MATSUYA, Noritoshi SEKIDO, Jun KIDA, Hiroko MASHIMO, Daisuke WAKAMATSU, Hiroki OKADA Tags: ORIGINAL ARTICLE Source Type: research