Fc RI (CD64) Receptors Are Widely Expressed on CNS Neurons and Are Required for Neuronal IgG Binding and Uptake: Implications for Antibody-Mediated Neuronal Injury (S50.007)

Conclusions:FcRI receptors are expressed on neurons throughout the brains of mice and rats and appear essential for IgG antibody incorporation into neurons. Although the biological function of neuronal Fc receptors is unknown, their presence suggests a mechanism through which antibodies reactive with intracellular neuronal proteins could gain access to their target antigens to cause neuronal injury and neurological disease.Study Supported by: This study was supported by a Merit Review award from the United States Department of Veterans Affairs and a grant from the Western Institute for Biomedical ResearchDisclosure: Dr. Liu has nothing to disclose. Dr. Hill has nothing to disclose. Dr. Wood has nothing to disclose. Dr. Clawson has nothing to disclose. Dr. Clardy has received personal compensation for activities with the DAVICK Group and Trinity Partners. Dr. Clardy's spouse holds stock and/or stock options in Quadex. Dr. Clardy has received research support from Western Institue for Biomedical Research. Dr. Carlson has received research support from Biogen. Dr. Greenlee has received royalty payments from MedLink and Merck.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Liu, S., Hill, K., Wood, B., Clawson, S., Clardy, S., Carlson, N., Greenlee, J. Tags: MS Novel Therapeutics and Animal Models Source Type: research