Astrocytic Junctional Adhesion Molecule-A (JAM-A) Promotes CNS Inflammatory Lesion Pathogenesis (S50.001)

Conclusions:Reactive astrocytes upregulate the cell adhesion molecule, JAM-A in inflammatory lesions, which promotes leukocyte migration and tissue damage during CNS inflammation and clinical disability in a model of MS.Study Supported by:S.H. is the recipient of grant funding from NIH R25NS079102 and a post-doctoral Neuroscience fellowship from the Leon Levy Foundation. This work was additionally supported by NINDS Research Grants, R01NS062703 and R01NS085103 (G.R.J.), and by NIH R24CA095823 (to the MSSM Microscopy Facility). Additional support was provided by National MS Society research grants RG5024 and RG-1501-02870 (G.R.J.), the Beker Foundation (G.R.J.), Noto Foundation (G.R.J.), and the Guthy-Jackson Charitable Foundation (G.R.J.).Disclosure: Dr. Chapouly has nothing to disclose. Dr. Gordon has nothing to disclose. Dr. Therattil has nothing to disclose. Dr. John has received research support from Genzyme and Teva Pharmaceuticals. Dr. Horng has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: MS Novel Therapeutics and Animal Models Source Type: research