In vivo imaging of CSD-induced activation of resident meningeal immune cells: implications for activation of meningeal nociceptors (S47.003)

Conclusions:The findings raise the possibility that activation of immune cells in the pia and dura after CSD may be involved in the activation of meningeal nociceptors, potentially by rendering the environment in which nociceptors reside more inflamed – a condition shown previously as sufficient for activation of nociceptors.Study Supported by: NIH/NINDS grants R37 NS079678, RO1 NS069847, R21 NS085510Disclosure: Dr. Schain has nothing to disclose. Dr. Melo-Carrillo has nothing to disclose. Dr. Strassman has nothing to disclose. Dr. Burstein has received personal compensation for activities with Allergan, GSK, and Merck as a consultant or member of the scientific advisory board.
Source: Neurology - Category: Neurology Authors: Tags: Headache: Basic and Clinical Science Source Type: research