Upregulation of inflammatory gene transcripts in periosteum of chronic migraineurs: implications to extracranial origin of headache (S47.002)

Conclusions:Because the up-regulated genes were linked to activation of white blood cells, production of cytokines, and inhibition of NFKB, and the down-regulated genes linked to prevention of macrophage activation and cell lysis, the findings suggest that the molecular environment surrounding periosteal pain fibers is inflamed. If confirmed in larger and independent studies, the findings can establish a basis for activation of trigeminovascular nociceptors that reach the affected periosteum through suture branches of intracranial meningeal nociceptors and/or somatic branches of the occipital nerve. This study provides the first set of evidence for localized extracranial pathophysiology in chronic migraine.Study Supported by:NIH/NINDS grants NS-079678, NS-069847; GlaxoSmithKline and R. Chemers NeusteinDisclosure: Dr. Burstein has received personal compensation for activities with Allergan, GSK, and Merck as a consultant or member of the scientific advisory board. Dr. Blake, MD has nothing to disclose. Dr. Perry, MD has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Headache: Basic and Clinical Science Source Type: research