Cortical spreading depression closes the paravascular space and impairs glymphatic flow: Implications for migraine headache. (S47.001)

Conclusions:Our findings demonstrate a link between migraine and the glymphatic system, and suggest a novel mechanism for regulation of glymphatic flow. Because CSD is involved in the production of many potentially harmful interstitial molecules, the blockade of their route of clearance could facilitate cortical changes, gliosis, and the headache.Study Supported by: NIH/NINDS grants R37 NS079678, RO1 NS069847Disclosure: Dr. Schain has nothing to disclose. Dr. Strassman has nothing to disclose. Dr. Melo-Carrillo has nothing to disclose. Dr. Burstein has received personal compensation for activities with Allergan, GSK, and Merck as a consultant or member of the scientific advisory board.
Source: Neurology - Category: Neurology Authors: Tags: Headache: Basic and Clinical Science Source Type: research