Mortality and comorbidities in narcolepsy - an Olmsted County, Minnesota community-based study (S14.005)
Conclusions:There was a non-significant increase in age-adjusted mortality with narcolepsy. Close attention should be given to the significantly increased comorbidities of obstructive sleep apnea, low back pain, depression, anxiety, and thyroid disease.Disclosure: Dr. Cohen has nothing to disclose. Dr. Mandrekar has nothing to disclose. Dr. St. Louis has received personal compensation for activities with Axovant, Inc. and Inspire, Inc. Dr. Silber has received royalty payments from UpToDate. Dr. Kotagal has received personal compensation for activities with INC Research. Dr. Kotagal has received royalty payments from UpToDate.
Date: Friday, 11 22, 2019; Speaker: Nicola Santoro, MD, PhD, Assistant Professor of Pediatrics (Endocrinology), Yale School of Medicine; Building 10 CRC; FAES 1&2
No abstract available
Discussion Although melancholically and nonmelancholically depressed patients differed significantly on several clinical characteristics, ECT outcome did not differ. Analyses may be hampered by a high prevalence of psychotic features. In nonpsychotic patients, CORE scores neared significance as predictor of remission, suggesting that CORE scores might be a distinguishing characteristic of melancholia in nonpsychotic patients and a clinical useful predictor of ECT response.
Conclusions The PDAS indeed accurately predicts response to and remission after ECT in (psychotic) depression and most pronouncedly so in older patients but seems to have no clear advantage over simply verifying the presence of psychotic symptoms. This could be the consequence of a ceiling effect, as ECT was extremely effective in patients with psychotic depression. ClinicalTrials.gov: Identifier: NCT02562846.
Conclusions Electroconvulsive therapy use appears to be substantially higher in China than in the United States and is associated with indicators of higher rather than lower functioning as reflected by independent associations with youth, employment, and fewer past hospitalizations, but also with behavioral noncompliance as reflected by involuntary admission, and has increased in recent years. Understanding United States–China discrepancies may further international understanding of the diverse roles of ECT in psychiatric practice.
Conclusions The risk of relapse after ECT is lower for patients with PPD and/or PPP than for patients outside the postpartum period, but the risk is nonetheless substantial in both groups.
No abstract available
Conclusions Generalized, high-amplitude, CPCs during ECT are a previously uncharacterized ictal waveform during ECT, which may have important scientific and clinical value. These complexes offer a specific marker for correlating clinical outcomes in ECT and greater understanding of generalized tonic-clonic seizures.
Conclusions Our data suggest that the beneficial effects of high frequency dTMS of the PFC cannot be attributed solely to its antidepressant effects.
Conclusion: These results indicate that VNS treatment can reduce the epileptiform activities and thus help in achieving better sleep quality for patients with epilepsy. Significance: The proposed approach can be used to investigate the effect of long-term VNS therapy on sleep quality.
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