Excessive daytime sleepiness predicts increased {beta}-amyloid accumulation in non-demented elderly: a longitudinal PiB-PET study (S14.004)

Conclusions:EDS in non-demented elderly was associated with an increased rate of β-amyloid accumulation particularly in areas associated with the default mode network (DMN). DMN regions are vulnerable to increased amyloid accumulation, suggesting that treating sleep disorders underlying EDS may be a targetable pathway towards prevention of β-amyloid accumulation in these areas.Study Supported by: NIHDisclosure: Dr. Carvalho has nothing to disclose. Dr. St. Louis has received personal compensation for activities with Axovant, Inc. and Inspire, Inc. Dr. Knopman has received personal compensation for activities with Lundbeck Pharmaceuticals.Dr. Knopman has received research support from Lilly Pharmaceuticals, Biogen and TauRX. Dr. Boeve has received research support from GE Healthcare, FORUM Pharmaceuticals, C2N Diagnostics and Axovant. Dr. Lowe received personal compensation for activities with Bayer Pharmaceuticals as a consultant. Dr. Roberts has nothing to disclose. Dr. Mielke has received personal compensation for activities with Lysosomal Therapeutics, Inc. as a consultant. Dr. Mielke has received research support from Biogen. Dr. Przybelski has nothing to disclose. Dr. Petersen received personal compensation for activities with Merck, Roche, Genentech, Biogen, and Eli Lilly and Co. Dr. Jack has received personal compensation for activities with Janssen Research & Development, LLC by providing consulting services. Dr. Jack has received research support from t...

Source: Neurology - April 17, 2017 Category: Neurology Authors: Carvalho, D., St. Louis, E., Knopman, D., Boeve, B., Lowe, V., Roberts, R., Mielke, M., Przybelski, S., Petersen, R., Jack, C., Vemuri, P. Tags: Highlights in Sleep Science Source Type: research