Glatiramer Acetate Induced Serum Sickness (P5.393)

Conclusions:The patient described developed signs, symptoms and laboratory data suggestive of serum sickness which was further supported by symptom recurrence with second challenge 21 days after initial cessation. Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. The clinical presentation of serum sickness is described as symptoms including fever, rash, arthralgia, nausea, vomiting, headaches and neurologic manifestations which can include peripheral neuropathy or brachial neuritis. Pathophysiologically it takes of 1–2 weeks or longer to manifest immunologic reaction to foreign substances following initial exposure with subsequent exposures resulting in reactivation in a little as three days.Disclosure: Dr. Ferguson has received personal compensation for activities with Biogen Idec and Sanofi-Genzyme as a speakers bureau member. Dr. Ferguson has received research support from Novartis and Sun Pharmaceuticals.
Source: Neurology - Category: Neurology Authors: Tags: Disease Modifying Therapy for Multiple Sclerosis: Risk Assessment and Safety Source Type: research