Comparative analysis of in-hospital outcomes between spontaneous vertebral and carotid arterial dissection at National level (P5.048)
Objective:To compare in-hospital outcomes of non-traumatic carotid versus vertebral artery dissections at national level.Background:Carotid and vertebral artery dissections are relatively common causes of ischemic stroke especially in younger population. Comparative analysis between these two entities at the national level is not well reported.Design/Methods:A retrospective study was conducted using national inpatient data (years 2008 to 2012). Patients were identified with a principal diagnosis of carotid dissection (ICD9 = 443.21) and vertebral dissections (ICD9 = 443.24). Baseline characteristics, co-morbidities, in-hospital complications, in-hospital procedures, length of stay, hospital charges and mortality were compared between the two groups.Results:A total of 1865 patients had either carotid (n= 1058, 56%) or vertebral (n= 807, 43.2%) artery dissection. Patients with vertebral artery dissections were younger (mean ± SD: 45.5 ± 15.7) years versus (mean ± SD: 48.5 ± 13.0) years, p
Two Clinical Nurse Specialist opportunities are available to contribute towards the provision of excellent patient care within our Endocrinology and Diabetes Service.One post will be for our Queen Elizabeth Hospital (QEHB) site and the other for our Heartlands, Good Hope and Solihull Hospital site (HGS). Successful candidates will join a team of experienced specialist nurses in a tertiary Endocrine referral centre and will be given full structured training and supervision to develop their skills in Endocrinology.Application deadline is2 February 2020. Visit www.jobs.nhs.uk for full details and to apply.
Researchers reports an over 50% drop in overall death rates among people with diabetes living in Hong Kong from 2001-2016; younger people with diabetes less likely to experience improvement in survival, however.Medscape Medical News
Conclusion It was safety to discontinued oral antiplatelet agents before operation, with no MACE and death in perioperative period. DOI: 10.3779/j.issn.1009-3419.2020.01.06
CONCLUSIONS Our results highlight that interaction of Nr4a1 and LKB1 can mitigate T2DM by activating the AMPK/SIRT1 signaling pathway and inhibiting NF-kappaB activation. This may offer new insight for T2DM treatment. PMID: 31939452 [PubMed - in process]
An article highlighting a lack of female invited speakers at a major scientific medical meeting caused International Stroke Conference organizers to encourage more women to attend and to speak at the event.Medscape Medical News
Authors: Du Z, Xu W, Chen X, Xu D, Li Y, Zhang H, Gao L PMID: 31937077 [PubMed - as supplied by publisher]
Authors: Saritas T, Floege J Abstract Patients with chronic kidney disease (CKD) are at increased risk for kidney failure, cardiovascular disease (CVD), and death. In fact, the likelihood of dying from CVD is markedly higher than that for reaching end-stage renal disease. Evidence-based management of comorbidities such as CVD remains challenging in patients with advanced CKD, as they were usually excluded from randomized controlled trials. This review focuses on the epidemiology, risk factors, and clinical manifestations of CVD in patients with advanced CKD. Specific topics of interest include diagnostic and therap...
Publication date: Available online 16 January 2020Source: Life SciencesAuthor(s): Milad Ashrafizadeh, Zahra Ahmadi, Saeed Samarghandian, Reza Mohammadinejad, Habib Yaribeygi, Thozhukat Sathyapalan, Amirhossein SahebkarAbstractMicroRNAs (miRs) are small non-coding pieces of RNA that are involved in a variety of physiologic processes such as apoptosis, cell proliferation, cell differentiation, cell cycle and cell survival. These multifunctional nucleotides are also capable of preventing oxidative damages by modulating antioxidant defense systems in a variety of milieu, such as in diabetes. Although the exact molecular mechan...
Driving blood glycaemia from hyperglycaemia to euglycaemia as fast as possible while avoiding hypoglycaemia is a major problem for decades for type-1 diabetes and is solved in this study. A control algorithm is designed that guaranties hypoglycaemia avoidance for the first time both from the theory of positive systems point of view and from the most pragmatic clinical practice. The solution consists of a state feedback control law that computes the required hyperglycaemia correction bolus in real-time to safely steer glycaemia to the target. A rigorous proof is given that shows that the control-law respects the positivity ...