Next Generation Sequencing to Diagnose West Nile Encephalitis in an Immunocompromised Patient (P3.301)

Conclusions:This case highlights the role of humoral immunity in early diagnosis and clearing WNV infection, as well as the importance of RT-PCR and NGS testing in patients with impaired B-cell immunity. NGS allowed for rapid confirmation and WNV load quantification in this patient. The early use of NGS for detection of infectious disease has clinical and economic relevance, especially in immunocompromised patients.Disclosure: Dr. Patel has nothing to disclose. Dr. Piquet has nothing to disclose. Dr. Schlaberg holds stock and/or stock options in IDbyDNA, which sponsored research in which Dr. Schlaberg was involved as an investigator. Dr. Greenlee has received royalty payments from MedLink and Merck. Dr. Ansari has nothing to disclose. Dr. Clardy has received personal compensation for activities with the DAVICK Group and Trinity Partners. Dr. Clardy's spouse holds stock and/or stock options in Quadex. Dr. Clardy has received research support from Western Institue for Biomedical Research.
Source: Neurology - Category: Neurology Authors: Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections II Source Type: research