Late-Onset Huntington Disease: Clinical Cases with Intermediate CAG Repeat Expansions (P2.010)

Conclusions:IR may confer risk of developing LOHD. Contributing factors may include comorbid neurodegenerative pathologies given advanced age or presence of other disease-modifying genes. Future longitudinal cohorts studying incidence of symptoms will be essential for understanding the spectrum of genetic susceptibility.Disclosure: Dr. McDermott has nothing to disclose. Dr. Bang has nothing to disclose. Dr. Liptak has nothing to disclose. Dr. Krishnakumar has nothing to disclose. Dr. Nelson has nothing to disclose. Dr. Geschwind has received personal compensation for activities with Best Doctors, Advanced Medical, Guidepoint Global, Gerson-Lehrman Group, Quest Diagnostics, and Biohaven Pharmaceuticals Inc. as a consultant.

Source: Neurology - April 17, 2017 Category: Neurology Authors: McDermott, D., Bang, J., Liptak, A., Krishnakumar, D., Nelson, A., Geschwind, M. Tags: Movement Disorders: Huntington ' s Disease, Chorea & amp;amp; Tardive Dyskinesia Source Type: research