Ring Enhancing Brain Lesions in a Patient With Sarcoidosis: A Diagnostic Challenge. (P1.306)

Conclusions:The current clinical observation serves to remind clinicians of the challenges faced in diagnosing brain ring-enhancing lesions, especially in patients with pre-existing brain disorders. Furthermore, it highlights the difficulty in treating invasive fungal infections in immunocompromised hosts. More studies are needed to establish the incidence and clinical course of invasive fungal infections in patients with sarcoidosis and infliximab therapy.Disclosure: Dr. Van Sanford has nothing to disclose. Dr. Obeidat has nothing to disclose. Dr. Zabeti has received personal compensation for activities with Biogen, Genzyme, and Acorda Therapeutics as a speaker.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

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Publication date: Available online 20 January 2020Source: LWTAuthor(s): Jian Ju, Yunfei Xie, Hang Yu, Yahui Guo, Yuliang Cheng, Ying Chen, Lijun Ji, Weirong YaoAbstractTo control the spoilage of bread products and reduce the costs associated with preventing their spoilage, the synergistic antifungal effects of natural agents against the main bread spoilage fungi Penicillium roqueforti and Aspergillus niger were studied. After screening 66 groups antifungals using the checkerboard method, only one combination, i.e., that of eugenol and citral (SEC), showed synergistic effects against both the fungi. Their average minimal in...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 21 January 2020Source: Food ChemistryAuthor(s): Oladapo Oluwaseye Olukomaiya, Oladipupo Qudus Adiamo, W. Chrishanthi Fernando, Ram Mereddy, Xiuhua Li, Yasmina SultanbawaAbstractThe effects of solid-state fermentation (SSF) with Aspergillus sojae, Aspergillus ficuum and their co-cultures on proximate composition, anti-nutritional factor, microbiological and functional properties of lupin flour (LF) were investigated. Fibre fractions, in vitro enzyme protein digestion (IVPD), total phenolic content, protein molecular distribution and colour attributes were also evaluated. Samples differed i...
Source: Food Chemistry - Category: Food Science Source Type: research
This study reports the validation of an enzyme-linked immunosorbent assay (ELISA) to detect bovine tuberculosis as an ancillary test to TST in dairy farms in Argentina.The estimated validation parameters were within the established requirements of the World Organization for Animal Health (OIE). The test demonstrated high repeatability, with coefficients of variation
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
CONCLUSIONS: Testing for S100B and calprotectin could be a useful screening tool to better predict IBD activity. PMID: 31957846 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This article focus on the synthesis of three 5-coordinated Sn(IV) complexes based on carboxylate ligand: 4-((4-methoxy-2-nitrophenyl)amino)-4-oxobutanoic acid. The complexes were characterized both in solid state (FT-IR, single crystal XRD and micro elemental analysis) as well as in solution state (1H, 13C and 119Sn NMR) and their results demonstrate that the carboxylate moiety of the ligand is linked with Sn atom. A 5-coordinated trigonal bipyramidal structure was obtained from crystallographic data for the reported complexes with little bit distortion from the ideal structure. Preliminary antifungal screening showed that...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, three tribenzoporphyrazines with dendrimeric peripheral substituents were subjected to in vitro antimicrobial photocytotoxicity study. One new magnesium(II) tribenzoporphyrazine with peripheral 3,5-bis(3,5-dimethoxybenzyloxy)benzylsulfanyl substituents was synthesized and subjected to physicochemical characterization using NMR, UV–Vis, and mass spectrometry techniques. In photochemical studies this molecule revealed moderate singlet oxygen generation ability (ΦΔDMF = 0.12, ΦΔDMSO = 0.13). The other two magnesium(II) tribenzoporphyrazines applied in the biological study were ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
ConclusionMore effective thromboprophylaxis and pre-test assessment is necessary for EOC patients. For prediction VTE events, D-dimer levels (>4.215 μg/ml) were the independent predictors before operation. Age and debulking surgery were the independent predictors post operation.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conclusion: For uveitis of unknown cause, diagnostic PPV is an effective, reliable, and relatively safe procedure for establishing the definite diagnosis and guiding further treatment. Positive therapeutic effect could also be achieved.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Only three new treatments available in 10 or more poorer countries, report findsMany antibiotics are unavailable in poorer countries despite higher infection rates, exacerbating the threat of drug-resistant superbugs, according to a report to bepresented to world leaders and the bosses of top pharmaceutical companies in Davos.The report, released by the Access to Medicine Foundation, an Amsterdam-based non-profit group, also shows that the number of new treatments being developed for common infectious diseases such as pneumonia, tuberculosis and gonorrhoea has fallen.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Antibiotics Business Davos 2020 Drugs MRSA and superbugs Health Source Type: news
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Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research
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