Assessment of radiation-induced white matter changes using myelin water imaging (P1.156)

Conclusions:MWI showed myelin loss in the region of the radiated AVM as a prominent feature of radiation necrosis1. Beyond the radiation field, WM normal 2 years earlier became T2 hyperintense with increased WC, in keeping with vasogenic edema, likely related to radiation induced obliterative vasculopathy2. The intact myelin however suggests a potentially reversible component. The MWC decrease in the lesion contralateral to the radiated AVM suggests spreading of the vasculopathic changes. MWI will be repeated after hyperbaric oxygen therapy.Disclosure: Dr. Lapointe has received personal compensation for activities with Roche for serving as a consultant. Dr. Litvin has nothing to disclose. Dr. Kolind has received personal compensation for activities Genzyme, Vertex Pharmaceuticals and Rocheas a speaker and/or consultant. Dr. Vasavour has nothing to disclose. Dr. Wiggermann has nothing to disclose. Dr. Li has received personal compensation for activities with Roche, Nuron and Opexa as a consultant. Dr. Traboulsee has received personal compensation for activities with Genzyme and Roche as a consultant. Dr. Traboulsee has received research support from Genzyme, Roche, and Chugai.
Source: Neurology - Category: Neurology Authors: Tags: General Neurology: The Eyes Have It and White Matter Matters Source Type: research