Impaired intracortical inhibition demonstrated in vivo in people with Dravet syndrome

Conclusions:
There were marked differences in inhibitory networks, detected using SICI paradigms, while other inhibitory and excitatory paradigms yielded normal results. These human data showing reduced GABAergic inhibition in vivo in people with Dravet syndrome support established animal models.

Source: Neurology - April 24, 2017 Category: Neurology Authors: Stern, W. M., Sander, J. W., Rothwell, J. C., Sisodiya, S. M. Tags: All Clinical Neurology, TMS, All Epilepsy/Seizures, All Genetics, Ion channel gene defects ARTICLE Source Type: research