Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses.

Microglia Loss Contributes to the Development of Major Depression Induced by Different Types of Chronic Stresses. Neurochem Res. 2017 Apr 22;: Authors: Tong L, Gong Y, Wang P, Hu W, Wang J, Chen Z, Zhang W, Huang C Abstract Recently, the loss and dystrophy of hippocampal microglia induced by chronic unpredictable stress (CUS) has been reported to mediate the development of major depression in mice whose microglial cells were labeled with enhanced green fluorescent protein-conjuncted-CX3C receptor type 1. However, whether this happens in endogenous microglia with no genetic intervention remains unclear. Here, we addressed this issue in mice treated with different types of chronic stresses, including the CUS, chronic restraint stress (CRS) and chronic social defeat stress (CSDS). Results showed that the cellular numbers, process lengths, soma areas and activation markers of endogenous hippocampal but not cortical microglia, were markedly reduced by CUS, CRS and CSDS treatment. Administration of mice with two classical stimulators of microglia, lipopolysaccharide (LPS) or macrophage colony-stimulating factor (M-CSF), reversed the CUS-, CRS- and CSDS-induced reductions in endogenous hippocampal microglial numbers, and also improved the CUS-, CRS- or CSDS-induced behavioral abnormalities, including the increases in the immobile time in the forced swimming test and tail suspension test, the inhibition of sucrose preference, and the decreas...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research