Study: New genes identified may unlock mystery of keloid development

(Henry Ford Health System) Researchers at Henry Ford Hospital in Detroit have uncovered previously unidentified genes that may be responsible for keloid scarring, a discovery that could unlock the mystery of keloid development and provide insight for more effective treatment.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Publication date: Available online 19 May 2020Source: Reports of Practical Oncology &RadiotherapyAuthor(s): Hitoshi Maemoto, Shiro Iraha, Ken Arashiroc, Kousei Ishigami, Fumikiyo Ganaha, Sadayuki Murayama
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Conditions:   Adipose Derived Stem Cells;   Keloid Interventions:   Procedure: Autologous Adipose Derived stem cell transplantation;   Drug: Triamcinolone Acetonide 40Mg/Ml Inj,Susp_#1 Sponsor:   Makerere University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Topical FTY720 induces M2 predominance and impairs angiogenesis. Therefore, its local immunosuppressive mechanisms differ from those of conventional immunosuppressive agents. Topical FTY720 can be a novel therapeutic option for abnormal scars that are difficult to control with corticosteroids. Its lymphocytopenic effects may be limited by careful optimization of the treatment regimen. PMID: 32377536 [PubMed - in process]
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Conclusions: This review condenses evidence for the active interaction between keratinocytes and fibroblasts in maintaining skin homeostasis and the altered homeostatic interplay between keratinocytes and dermal fibroblasts in scleroderma and scleroderma-like disorders.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
IJERPH, Vol. 17, Pages 3229: Effect of Kelulut Honey on the Cellular Dynamics of TGFβ-Induced Epithelial to Mesenchymal Transition in Primary Human Keratinocytes International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17093229 Authors: Abid Nordin Shiplu Roy Chowdhury Aminuddin Bin Saim Ruszymah Bt Hj Idrus Over-induction of epithelial to mesenchymal transition (EMT) by tumor growth factor beta (TGFβ) in keratinocytes is a key feature in keloid scar. The present work seeks to investigate the effect of Kelulut honey (KH) on TGFβ-induced EMT in human primary k...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: Available online 3 May 2020Source: Life SciencesAuthor(s): Mingyuan Xu, Jiaqi Sun, Yijia Yu, Qianqian Pang, Xiaohu Lin, May Barakat, Rui Lei, Jinghong Xu
Source: Life Sciences - Category: Biology Source Type: research
In conclusion, miR-4417 and CyclinD1 may be potential therapeutic targets for the treatment of keloid. PMID: 32345773 [PubMed - in process]
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
Conclusions: High-quality randomized controlled trials are currently lacking, and the existing literature is predominately not specific to use of 5-FU on the face. These studies, however, suggest that intralesional 5-FU is safe and probably more effective than other options in the management of cutaneous scars in the oculofacial region. The delivery methods, timing, dosing, and concomitant therapies were highly variable. Further high-quality controlled studies specific to oculofacial scars may be indicated to assess the efficacy of 5-FU and to establish the best protocols for administering this medication.
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Major Reviews Source Type: research
The JAK2/STAT3 pathway inhibitor, AG490, suppresses the abnormal behavior of keloid fibroblasts in vitro. Int J Mol Med. 2020 Apr 29;: Authors: Zhou Y, Sun Y, Hou W, Ma L, Tao Y, Li D, Xu C, Bao J, Fan W Abstract AG490 is a selective inhibitor of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. The present study examined its effects on the abnormal behavior of human keloid fibroblasts (HKFs) and evaluated its potential use in the treatment of keloids. Human normal fibroblasts (HNFs) and HKFs were treated with increasing concentrations of...
Source: International Journal of Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Med Source Type: research
AbstractBackgroundAlthough keloids and hypertrophic scars are common benign hyperproliferative growths of dermal fibroblasts, the clinical problems including physical and psychological problems are significant and impairing, with few proven treatments. Intralesional triamcinolone acetonide (TAC) and combination of TAC with 5-fluorouracil (5-FU) are widely used to treat keloids and hypertrophic scars, but their efficacy and safety remain controversial.MethodsWe systematically searched MEDLINE, EMBASE, Cochrane Library, and CNKI for relevant trials.ResultsThe mean scar height and the erythema score in the TAC  +&thins...
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
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