Premenstrual Dysphoric Disorder Symptoms Following Ovarian Suppression: Triggered by Change in Ovarian Steroid Levels But Not Continuous Stable Levels.

CONCLUSIONS: The findings demonstrate that the change in estradiol/progesterone levels from low to high, and not the steady-state level, was associated with onset of PMDD symptoms. Therapeutic efforts to modulate the change in steroid levels proximate to ovulation merit further study. PMID: 28427285 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28427285?dopt=Abstract

Source: The American Journal of Psychiatry - April 21, 2017 Category: Psychiatry Authors: Schmidt PJ, Martinez PE, Nieman LK, Koziol DE, Thompson KD, Schenkel L, Wakim PG, Rubinow DR Tags: Am J Psychiatry Source Type: research