α-Mangostin decreases β-amyloid peptides production via modulation of amyloidogenic pathway.

CONCLUSIONS: Our data demonstrate that α-M decreases Aβ production through inhibiting activities of β-secretase and likely γ-secretase in the amyloidogenic pathway. The current data together with previous study indicated that α-M could be a novel neuroprotective agent through intervention of multiple pathological processes of AD.
PMID: 28429536 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - April 21, 2017 Category: Neuroscience Authors: Zhao LX, Wang Y, Liu T, Wang YX, Chen HZ, Xu JR, Qiu Y Tags: CNS Neurosci Ther Source Type: research