New Clinical Advisory Issued by National Heart, Lung, and Blood Institute
The National Institutes of Health’s National Heart, Lung, and Blood Institute has suspended enrollment for the clinical study BMT CTN 0901 conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) after preliminary data appeared to show benefit for one approach to the intensity of conditioning for allogeneic stem cell transplantations in patients […]
The week of April 23-27 has been designated as National Pediatric Transplant Week. This week is to bring attention to the great need for organ donations and to honor donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list. Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
This study demonstrates that small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro. Six groups were prepared to carry out remineralization on artificially created lesions on enamel: (1) no treatment, (2) Ca2+ and PO43- only, (3) 1100 ppm fluoride (F), (4) 20 000 ppm F, (5) 1100 ppm F and peptide, and (6) peptide alone. While the 1100 ppm F sample (indicative of common F content of toothpaste for homecare) did not deliver F to the thinly deposited mineral layer, high F test sample (indicative of clinical varnish treatment) formed mainly C...
We describe our unique approach of aiming for ASCT one year after HT so that patients can remain in hematological remission with current chemotherapy and to allow patients complete recovery from OHT.
Heart transplantation remains the standard treatment for end stage heart failure patients. However, hemodynamic instability after brain death (BD) could affect posttransplant graft function. Conditioned medium (CM) from bone marrow derived mesenchymal stem cells (MSCs) was found to protect the myocardium against ischemia/reperfusion (IR), this finding appears to be mediated via activation of the phosphatidylinositol 3 kinase (PI3K) signalling. We hypothesized that CM added to a preservation solution (Custodiol) improves in vivo left ventricular (LV) graft function after transplantation.
Ex vivo lung perfusion (EVLP) has emerged as a modern preservation technique developed to evaluate candidate donor lungs in a normothermic and metabolically active state. Donor leukocytes are linked to the development of transplant related ischemia reperfusion injury, primary graft dysfunction, and acute rejection. Pharmacologic strategies to enhance donor leukocyte depletion during EVLP have not yet been described. Plerixafor (Mozobil) is a clinically available CXCR4 receptor antagonist, which disrupts the interaction between CXCR4 and SDF-1 α and facilitates mobilization of hematopoietic stem cells into peripheral circulation.
For clinical application of cardiomyocytes derived from induced pluripotent stem cells (iPSC-CM), immunological response to transplants should be great concern; however, innate immunological response after in vivo transplantation has not been fully elucidated. We hypothesized that natural killer cells (NKCs) may play an important role in innate immune rejection to transplanted iPSC-CMs.
Contraction of interventricular septum (IVS) is an important component of right ventricular (RV) function. We investigated the effects of IVS stem cell injections on RV function in patients with non-ischemic dilated cardiomyopathy (DCM).
Introduction: Respiratory complications of Hematopoietic Stem Cell Transplantation (HSCT), both allogeneic and autologous, comprise the majority of its morbidity and mortality. Chronic Graft Versus Host Disease (cGVHD) is a multisystem disorder that is a common complication of allogeneic Hematopoietic Stem Cell Transplantation (HSCT). Bronchiolitis Obliterans Syndrome (BOS) considered part of the spectrum of cGVHD pulmonary manifestations, affect 5.5% of transplant recipients. The prognosis of BOS remains poor.
Pulmonary graft versus host disease (GVHD), manifest as bronchiolitis obliterans, bronchiectasis and pulmonary fibrosis, is a serious complication of haematopoietic stem cell transplantation (HSCT) causing respiratory failure and death. There are limited therapeutic options for severe cases other than lung transplantation (LTx) but
CONCLUSION: Our findings indicate that, when posaconazole is co-administered, the dosage of sirolimus and tacrolimus should be reduced by 60%-70% and for cyclosporine and by 30%-40% following allogeneic hematopoietic stem cell and solid-organ transplantation. PMID: 29603686 [PubMed - in process]