CORR Insights( ®): Can a Bayesian Belief Network Be Used to Estimate 1-year Survival in Patients With Bone Sarcomas?
CORR Insights(®): Can a Bayesian Belief Network Be Used to Estimate 1-year Survival in Patients With Bone Sarcomas? Clin Orthop Relat Res. 2017 Apr 18;: Authors: Maltenfort M PMID: 28421515 [PubMed - as supplied by publisher]
The differential diagnosis of fibroids could be challenging with other uterine masses including adenomyomas or uterine cancers and sarcomas. Minimally Invasive procedures including morcellation mandates a thorough imaging and if possible histologic analyses. To date such a pathologic approach has a very poor accuracy, even conducted under ultrasound, MRI or hysteroscopic guidance. A targeted biopsy requires the development of state of the art imaging and robotics to enable a secure, reproducible, and accurate sampling.
ConclusionsPhysicians should be alert of this tumor despite its rarity because diagnostic delays increase mortality. In this report, we summarize the features that differentiate PPAS from PE and the importance of imaging in diagnosing the tumor.
Conclusions: In selected patients, local treatments contribute to controlling oligoprogression for a long time, allowing the continuation of systemic treatment and prolongation of overall survival (OS). Increasing biological and clinical knowledge is improving the accuracy in identifying patients to apply for local ablative therapies.
We report the case of a 17-year-old patient with recurrent hemorrhagic pericardial effusion, who was diagnosed with primary pericardial fibrosarcoma. However, multiple radiological examinations, including CT and [18F] FDG/PET-CT, suggested the presence of fluid and no sign of tumor. Actually, when a patient presents with recurrent hemorrhagic pericardial effusions, pericardial tumors must be taken into account as part of the differential diagnosis.
Authors: Bang S, Kim Y, Chung MS, Park JS, Choi YY, Shin SJ Abstract Histiocytic sarcoma is a rare hematologic malignancy, with very few cases of primary histiocytic sarcoma of the breast described in English scientific literature. Herein, we describe a case of primary histiocytic sarcoma of the breast in a 75-year-old woman, with no clinical history of malignant tumors, who presented with a palpable solitary breast mass. Microscopically, the resected breast mass showed large pleomorphic cells, some multinucleated giant cells, and admixed inflammatory components. The pleomorphic tumor cells further showed a diffuse...
Condition: Undifferentiated Pleomorphic Sarcoma Intervention: Device: ExAblate 2000/2100 Magnetic Resonance-guided Focused Ultrasound (MRgFUS) Sponsors: Matthew Bucknor; Focused Ultrasound Foundation Not yet recruiting
CONCLUSIONS: HGESSs are defined by the presence of YWHAE rearrangement. These tumors present at higher stage and have poorer prognosis. They may not respond to hormonal therapy and may be treated with chemotherapy. Cyclin D1 though not specific remains a sensitive tool to triage endometrial stromal sarcomas for this FISH study.
Stephens PJ, Zhu VW, Ou SI, Lovly CM, Gounder M, Schrock AB, Ross JS, Miller VA, Klempner SJ, Ali SM Abstract PURPOSE: Amplifications of receptor tyrosine kinases (RTKS) are therapeutic targets in multiple tumor types (e.g. HER2 in breast cancer), and amplification of the chromosome 4 segment harboring the three RTKs KIT, PDGFRA, and KDR (4q12amp) may be similarly targetable. The presence of 4q12amp has been sporadically reported in small tumor specific series but a large-scale analysis is lacking. We assess the pan-cancer landscape of 4q12amp and provide early clinical support for the feasibility of targeting th...
Conditions: Sarcoma; Sarcoma,Soft Tissue; Sarcoma of Bone; Carcinosarcoma Intervention: Sponsor: IKF Klinische Krebsforschung GmbH at Krankenhaus Nordwest Recruiting