Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke ’s cell morphology

ConclusionsmiR-106b~25 and its host gene MCM7 are potential novel biomarkers for invasive ACTH-immunopositive pituitary adenomas. Additionally, they are both significantly upregulated in rare Crooke ’s cell adenomas and might therefore contribute to their aggressive phenotype.
Source: Pituitary - Category: Endocrinology Source Type: research