Frontal brain volume reduction due to antipsychotic drugs?

This article reviews the results of longitudinal studies on frontal brain volume reduction in patients with schizophrenia spectrum disorders and focuses on the relationship with antipsychotic treatment. Based on a systematic literature search all studies were included in which results on changes of brain volumes over a longer period of time were correlated with antipsychotic treatment dose and disease severity. The findings indicate that there is evidence for grey and white matter volume changes of the frontal brain, which cannot be explained by the severity of the disease alone but are also very likely a manifestation of long-term effects of antipsychotics. Whether second generation antipsychotics have an advantage compared to first generation antipsychotics is currently unclear. Considering the contribution of antipsychotics to the changes in brain structure, which seem to depend on cumulative dosage and can exert adverse effects on neurocognition, negative and positive symptoms and psychosocial functioning, the guidelines for antipsychotic long-term drug treatment should be reconsidered. This is the reason why we and others recommend prescribing the lowest dose necessary to control symptoms. In non-schizophrenic psychiatric disorders, antipsychotics should be used only with great caution after a careful risk-benefit assessment. Moreover, treatment approaches which can help to minimize antipsychotic medication or even administer them only selectively are of increasing impor...
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research

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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Conclusion: G. glauca and their derivatives products (GRF and galphimines) were able to interact with the dopaminergic and glutamatergic drugs and to block different behaviors associated with some of the positive, negative, and cognitive symptoms of induced schizophrenia in mice. It is necessary to continue with this research, in order to identify their mechanism of action. PMID: 31428176 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Molecular Psychiatry, Published online: 22 August 2019; doi:10.1038/s41380-019-0479-0The complement system in schizophrenia: where are we now and what’s next?
Source: Molecular Psychiatry - Category: Psychiatry Authors: Source Type: research
AbstractThe dopamine transporter is coded by theSLC6A3 gene and plays an important role in regulation of the neurotransmitter dopamine. To detect the association between theSLC6A3 gene and the risk of schizophrenia, 31 case-control articles were included in this meta-analysis. There were 23 studies with 40  bp VNTR (3246 cases and 3639 controls), 4 studies with rs40184 (2020 cases and 1674 controls), rs6347 (1317 cases and 1917 controls), rs403636 (2045 cases and 1704 controls), and rs2975226 (849 cases and 904 controls); and 3 studies with rs12516948 (1920 cases and 1569 controls), rs27072 (984 case s and 1015 contro...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: The present study demonstrated that the IST of 1-ms BP-BL ECT following sodium thiopental anesthesia in Korean patients was comparable to those reported in previous literature. The IST was associated with age, gender, and dose of sodium thiopental. PMID: 31429220 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Authors: Theodoropoulou S, Gialouris AG Abstract Brain is an organ with the highest lipid concentration in the body. Cellular membrane lipids can affect both the positioning and the functioning of membrane proteins, thus regulating several cell actions. Changes in the lipid composition of cell membrane can modulate the microenvironment and consequently the function of its proteins, e.g. neurotransmission. Some of the first studies on the subject have shown a negative correlation between serum cholesterol levels and depression, suicidality and behavioral disorders. Several studies -but not all- have found decreased ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
Authors: Kalogerakis Z, Petroutsou A, Chatzakis A, Ploumpidis D, Papageorgiou C, Economou M Abstract Psychosocial rehabilitation for people with chronic-severe mental illness mainly aims to social integration by restoring independent functioning in the community, improving quality of life, and addressing risk factors that lead to social disability. Support groups (SG) are usually part of this multilevel mental health process. Given that non-adherence to treatment is a common phenomenon in people with chronic- severe mental illness, the aim of the current study was to identify which factors influence members' attend...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
Authors: Shah P, Iwata Y, Brown EE, Kim J, Sanches M, Takeuchi H, Nakajima S, Hahn M, Remington G, Gerretsen P, Graff-Guerrero A Abstract Although clozapine is the main antipsychotic medication for treatment-resistant schizophrenia, 40-70% of patients on clozapine have persistent psychotic symptoms (i.e. ultra-treatment-resistant schizophrenia, UTRS). We aimed to examine clozapine response/non-response patterns in patients with treatment-resistant schizophrenia, as well as determine patient clinico-demographic factors associated with long-term clozapine non-response. Clinico-demographic characteristics of 241 patie...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
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Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
 Schizophrenia does not just affect the person with schizophrenia, but their families, also. This episode of Inside Schizophrenia explores the family relationships impacted by schizophrenia, both immediate and extended.  Two guests join us. The first is Chrisa Hickey, who is the mother of an adult son with schizophrenia and started an online site for parents of children who have a severe mental illness. The other guest, interviewed by co-host Gabe Howard, is Janel Star Withers, mother of host Rachel Star Withers. Janel shares her experiences with raising a schizophrenic daughter.  Host Rachel Star Withers, a d...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Children and Teens Family Inside Schizophrenia Parenting Bipolar disorder and schizophrenia Family Mental Health family mental illness Helping Families in Mental Health Crisis life with schizophrenia Mental Disorder Mental illness and Source Type: blogs
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