Antiepileptics in women of childbearing age and during pregnancy : Comparison of specialized information with the current state of knowledge in Germany and Switzerland.

DISCUSSION: The information regarding use in women of childbearing age and during pregnancy provided by the SmPCs is heterogeneous and poorly reflects the current state of knowledge. Regular updates of SmPCs are warranted in order for these documents to be of reliable use for health care professionals. PMID: 24861194 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research

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Conclusion: Surgical planning of the gravid patient undergoing laparoscopic surgery should include demarcation of the most superior aspect of the uterine fundus, either via physical examination or, if not conclusive, via preoperative or intraoperative ultrasound. PMID: 31427852 [PubMed - in process]
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - Category: Surgery Tags: JSLS Source Type: research
This article is part of a Special Issue entitled: Membrane Transporters and Receptors in Pregnancy Metabolic Complications edited by Luis Sobrevia.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 20 August 2019Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Margarita G. Skalnaya, Alexey A. Tinkov, Yulia N. Lobanova, Jung-Su Chang, Anatoly V. SkalnyAbstractBackgroundIron (Fe), copper (Cu), and manganese (Mn) play a significant role in female reproduction and fetal development. At the same time, high levels of metals may exert toxic effects. Correspondingly, both excess and deficiency of essential trace elements were shown to be associated with female infertility and adverse pregnancy outcome, although the existing data are rather contradictory. Therefore, the ob...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
ConclusionsThese findings support day 3 cleavage stage embryo transfer instead of growing on to day 4-6 for blastocyst stage transfer when only a single embryo is available.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
AbstractBaliyan et al. (in J Obstet Gynecolhttps://doi.org/10.1007/s13224-019-01220-8,2019) in their study evaluated the sensitivity and specificity of MCV and MCH for the screening of the beta thalassemia trait in late pregnancy. However, they failed to rule out iron deficiency, which is a confounding factor for low MCV and MCH; as a result, they observed low specificity. Authors recommend ruling out iron deficiency prior to screening for beta thalassemia and preferably in the first trimester of pregnancy so that antenatal diagnosis can be performed in high-risk subjects if necessary.
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
We report two cases of metoclopramide-induced acute dystonia in pregnant women and consider the role of genetic variation in the pathogenesis of the adverse effect. By whole-gene sequencing, we found that both women were CYP2D6 poor metabolisers. We theorise that CYP2D6 governs the risk of metoclopramide-related acute dystonia through its role in the synthesis of serotonin, which inhibits the dopamine tone. The effect of CYP2D6 poor metabolism is exaggerated by rises in the oestrogen levels during pregnancy, as the hormone augments dopamine sensitivity. Together, the two factors may create a hyper-dopaminergic state that i...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Authors: Wan Ab Rahman WS, Abdullah WZ, Husin A, Nik Mohd Hassan NFF, Hassan MN, Zulkafli Z Abstract INTRODUCTION: Acquired haemophilia A (AHA) is a rare acquired bleeding disorder caused by polyclonal immunoglobulin G autoantibodies against clotting factor VIII (FVIII). The incidence was reported to be rare occurring in 0.2- 4 cases/million/year. Patients may present with different clinical manifestations to various specialties. Early recognition of the disease contributes to favourable clinical outcome. CASE SERIES: Here, we reported five cases of this disorder with different clinical presentations from two t...
Source: Malaysian Journal of Pathology - Category: Pathology Tags: Malays J Pathol Source Type: research
CONCLUSIONS: There were no significant differences in the clinical and obstetric variables analysed between pregnant women exposed to DMDs, unexposed, and HPW. PMID: 31420082 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
We report a case of splenic trauma during the third trimester of pregnancy that was successfully treated by arterial embolization with preservation of the spleen. This rarely reported management strategy during pregnancy had a favorable outcome. Such a strategy should be discussed and considered, taking into account maternal, obstetrical and fetal factors.
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
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