The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers.

The association of occupational metals exposure and oxidative damage, telomere shortening in fitness equipments manufacturing workers. Ind Health. 2017 Apr 14;: Authors: Ko JL, Cheng YJ, Liu GC, Hsin IL, Chen HL Abstract The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants. MDA levels varied according to workers' roles at the manufacturing plants, and showed a trend as cutting > painting > welding > administration workers. Welders had marginally shorter average telomere lengths than the administrative workers (p=.058). Cr and Mn levels were significantly greater in welders than they were in administrative workers. There were significantly positive correlations between MDA and Cr and Mn levels, the major components of welding fume. However, the association would be eliminated if co-metals exposure were considered simultaneously. In future, telomere length and MDA mig...
Source: Industrial Health - Category: Occupational Health Tags: Ind Health Source Type: research