Patient and caregiver perspectives on decision support for symptom and quality of life management during cancer treatment: Implications for eHealth

ConclusionsPatients were faced with an overwhelming amount of information and relied on their caregivers to help navigate the complexities of cancer care and self‐manage SQL. Health technologies can provide informational support, however, decision support needs to span multiple venues to avoid increasing disparities caused by a digital divide.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research

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This study investigated the relationship of American Indian boarding school attendance and chronic physical health. We hypothesized boarding school attendance would be associated with an increased number of chronic physical health problems. We also examined the relationship between boarding school attendance and the 15 chronic health problems that formed the count of the chronic health conditions. American Indian attendees had a greater count of chronic physical health problems compared with nonattendees. Father's attendance was independently associated with chronic physical health problems. Attendees were more likely to h...
Source: Family and Community Health - Category: Primary Care Tags: Health Equity Source Type: research
Publication date: January 2019Source: Journal of Functional Foods, Volume 52Author(s): Meimei Wang, Hang Ma, Zhaoxing Li, Yang Yu, Liangyu Liu, Xuegang Li, Xiaoli YeAbstractThe aim of this study was to explore the inhibitory effects of SPG-56 and intestinal microbes on the progression of colorectal cancer (CRC). An in-vivo model of CRC was generated by transplanting BALB/c nude mice with HCT-116 cells and tumor progression was monitored after treatment with SPG-56 (150 mg/kg), Lactobacillus fermentum (2 × 108 cfu/0.2 ml) + SPG-56 (150 mg/kg) and short-chain fatty acids (SCFAs, 20 mM/0.2 ml). All thr...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study aimed to examine the growth inhibitory effect of the lower concentrations of β-carotene in HepG2 cells. Beta-carotene purified from Gracillaria sp. inhibited viability of HepG2 cells in a concentration-dependent manner. This growth inhibitory effect was well correlated with increased apoptotic cell death. Apoptosis induction by β-carotene was associated with increased caspase-3 activity and reduced mitochondrial membrane potential. Western blot analysis showed a significant decrease in the expression of Bcl-2, PARP, and NF-kB protein, and an increase in the protein expression of Bax. Beta-carotene also...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Conclusions: Renal Klotho expression in human sepsis-acute kidney injury and in mouse models of sepsis was significantly decreased and correlated with renal damage. Recombinant Klotho intervention diminished organ damage, inflammation, and endothelial activation in the kidney and brain of lipopolysaccharide-challenged mice. Systemic Klotho replacement may potentially be an organ-protective therapy for septic patients to halt acute, inflammatory organ injury.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
CONCLUSIONS The results of this research indicate that the metastases of non-small cell lung cancer can predict RET rearrangement of the primary tumor tissue in the majority of cases. Testing for RET rearrangement in metastases can be used as an alternative to testing of primary tumor tissue if it is inaccessible. PMID: 30429449 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Di C, Zhang Q, Wang Y, Wang F, Chen Y, Gan L, Zhou R, Sun C, Li H, Zhang X, Yang H, Zhang H Abstract Exosomes are nanoscale vesicles shed from all cell types and play a major role in communication and transportation of materials between cells due to their ability to transfer proteins and nucleic acids from one cell to another. Analogous in size and function to synthetic nanoparticles, exosomes offer many advantages, rendering them the most promising candidates for targeted drug or gene delivery vehicles. Exosomes can also induce chemoresistance or radioresistance of tumor cells. Studies about the related m...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Authors: Vodovar D, Langrand J, Tournier N, Mégarbane B Abstract Since the 2000s, a concerning increase in opioid-analgesic-related overdoses and deaths has been reported in the United States. In contrast with opioid overdoses reported in the 80-90s mostly involving heroin, currently it is the misuse of opioid analgesics that is mainly responsible for opioid overdoses. This crisis is related to factors (not limited to the US) which occurred during the 90s and which have led to a broad prescription of opioids in non-cancer pain. In Europe and France, there is (but to a much lesser extent) an increase in ...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Non-small cell lung cancer (NSCLC) represents more than about 80% of the lung cancer. The early stages of NSCLC can be treated with complete resection with a good prognosis. However, most cases are detected at...
Source: BMC Medical Genomics - Category: Genetics & Stem Cells Authors: Tags: Research Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Publication date: Available online 15 November 2018Source: The LancetAuthor(s): Hisham Mehanna, Max Robinson, Andrew Hartley, Anthony Kong, Bernadette Foran, Tessa Fulton-Lieuw, Matthew Dalby, Pankaj Mistry, Mehmet Sen, Lorcan O'Toole, Hoda Al Booz, Karen Dyker, Rafael Moleron, Stephen Whitaker, Sinead Brennan, Audrey Cook, Matthew Griffin, Eleanor Aynsley, Martin Rolles, Emma De WintonSummaryBackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatmen...
Source: The Lancet - Category: General Medicine Source Type: research
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