Human circulating and tissue gastric cancer stem cells display distinct epithelial –mesenchymal features and behaviors

ConclusionsAs expected, the CGCSCs indeed showed extremely invasive and metastatic properties. They also exhibited distinctive mesenchymal phenotypes, high self-renewal, proliferative capabilities, tumor induction and low apoptosis. Interestingly, CGCSCs show small cell-size than TGCSCs (tissue gastric cancer stem cells). The findings might help us to understand the biological characteristic of CGCSCs deeply, and give light to strategies for cancer therapies.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research