Study: Brain stimulation can work –if properly timed

—– Electrical Stimulation To Boost Memory: Maybe It’s All In The Timing (NPR): “People with a brain injury or dementia often struggle to remember simple things, like names or places. In research published Thursday in the journal Current Biology, scientists have shown it may be possible to improve this sort of memory using tiny pulses of electricity — if they’re properly timed…They tried the approach with a group of patients who had severe epilepsy. These people already had electrodes temporarily implanted in their brains as part of their treatment. And that gave the scientists a way to deliver tiny pulses of electricity to areas deep in the brain… “When memory was predicted to be poor,” he explains, “brain stimulation enhanced memory, and when it was predicted to be good, brain stimulation impaired memory.” In other words, on a bad memory day, stimulation helped. On a good day, it hurt. When stimulation was delivered to the right place at the right time, the researchers found, it could improve memory performance among the patients by as much as 50 percent.”   The Study Direct Brain Stimulation Modulates Encoding States and Memory Performance in Humans (Current Biology) Summary: People often forget information because they fail to effectively encode it. Here, we test the hypothesis that targeted electrical stimulation can modulate neural encoding states and subsequent memory outcomes. Us...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology boost memory brain-injury brain-stimulation dementia electrical stimulation electrodes improve memory performance neu­rotech­nolo­gies Source Type: blogs

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The prevalence of epileptic seizures is increased in patients in the clinical stages of Alzheimer's disease (AD) when compared to age-matched cognitively normal populations. In previously reported work from the Presentation of Epileptic Seizures in Dementia (PrESIDe) study, we identified a clinical suspicion of epilepsy in between 12.75 and 28.43% of patients with AD recruited from a memory clinic. EEGs were not performed in this study. Patients with epilepsy performed similarly to patients without epilepsy on cognitive testing at the time of recruitment but were more impaired on two measures of everyday functioning [Cambr...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
__________ Just a heads-up about a great event later this week in Dublin, Ireland, for those working on virtual and augmented reality and healthcare innovation. When: Thu Dec 5, 2019 8:00 am — Fri Dec 6, 2019 5:00 pm. Where: Davenport Hotel Featured sessions include: Day 1 – Thursday, December 5th, 2019 9:00am‑9:30am Introductions, Welcome and Setting The Stage Robert Fine, Executive Director, International Virtual Reality and Healthcare Association (IVRHA) 9:30am-10:30am Keynote Presentation:  Virtual Reality and Healthcare: The Past, The Present and The Future Dr. Walter Gree...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology augmented reality Dublin healthcare healthcare innovation virtual-reality Source Type: blogs
To the Editor In their recent study, Coupland et al conclude that, at sufficiently high dosages, exposure to 11 disparate anticholinergic drug classes is associated with increases in observed dementia. They focus on 4 drug classes as particularly concerning: antidepressants, bladder antimuscarinic drugs, antiparkinson drugs, and epilepsy drugs.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
This study finds that tau pathology itself is sufficient to alter seizure susceptibility in a rodent model, indicating that the disease process is crucial in the emergence of epilepsy in patients with tauopathy.
Source: Neuroscience - Category: Neuroscience Source Type: research
Abstract Brain perfusion SPECT can be used in the diagnosis of various neurologic or psychiatric disorders, e.g. stroke, epilepsy, dementia and posttraumatic stress disorder. As traditional SPECT provides limited resolution and sensitivity, we recently proposed a high resolution focusing multi-pinhole clinical SPECT scanner dubbed G-SPECT-I (Beekman et al 2015). G-SPECT-I achieves data completeness in the scan region of interest by making small translations of the patient bed while using projections from all bed positions together for image reconstruction. A strategy to restrict the number of bed translations is d...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
CONCLUSIONS: These findings suggest that the RBANS has utility in evaluating cognition in patients with epilepsy and can differentiate TLE and non-TLE patients. Additionally, number of AEDs appears to be associated with global cognitive performance in adults with epilepsy. PMID: 31761928 [PubMed - as supplied by publisher]
Source: Archives of Clinical Neuropsychology - Category: Psychiatry & Psychology Authors: Tags: Arch Clin Neuropsychol Source Type: research
ConclusionELP4 rs986527 polymorphism affected the incidence of clinical symptoms and the levels of TNF ‐α and IL‐1β in patients with intracranial arachnoid cysts.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Anny Reyes, Sanam J. Lalani, Erik Kaestner, Kiera Hooper, Austin Chen, Anna Christina Macari, Brianna M. Paul, Bruce P. Hermann, Carrie R. McDonaldAbstractCerebrovascular risk factors (CVRFs) and comorbid cardiovascular and metabolic disease have been linked to accelerated cognitive aging and dementia in the general population; however, the contribution of these comorbidities to the risk of post anterior temporal lobectomy (ATL) memory decline has been unexamined. We explored the effects of CVRFs on postoperative verbal memory decline in a c...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Abstract Cerebrovascular risk factors (CVRFs) and comorbid cardiovascular and metabolic disease have been linked to accelerated cognitive aging and dementia in the general population; however, the contribution of these comorbidities to the risk of post anterior temporal lobectomy (ATL) memory decline has been unexamined. We explored the effects of CVRFs on postoperative verbal memory decline in a cohort of 22 patients with left temporal lobe epilepsy (LTLE) who completed pre- and one-year postsurgical neuropsychological testing. Diagnoses of interest included preoperative cardiovascular and metabolic disorders, as...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
CONCLUSIONS: The present results provide evidence of BBB dysfunction in iNPH. The BBB leakage of blood proteins may render for impaired neurovascular units in iNPH patients. PMID: 31712085 [PubMed - as supplied by publisher]
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
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