Systemic sclerosis: Knocking out FLI1 to clear the AIRE

Nature Reviews Rheumatology 13, 259 (2017). doi:10.1038/nrrheum.2017.39 Author: Jessica McHugh A new mouse model has shed light on the autoimmune phenotype observed in systemic sclerosis (SSc) and the unexplained tissue specificity of this disease. In this mouse model, conditional deletion of the transcription factor FLI1 in epithelial cells recapitulates the disease phenotype observed in patients
Source: Nature Reviews Rheumatology - Category: Rheumatology Authors: Tags: Research Highlight Source Type: research