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Carcinoma of the penis.

Carcinoma of the penis. Arch Esp Urol. 2017 Apr;70(3):373-374 Authors: Menéndez López V, Hernández Pozo H, Urmeneta Sanroma JM, Díaz Cárdenas D, Castells Puñet H, Fernández Zuazu J PMID: 28422040 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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Publication date: March 2018 Source:Human Pathology: Case Reports, Volume 11 Author(s): Sabina Signoretti, Jon C. Aster Notch receptors (NOTCH1-4) participate in a signaling pathway that is frequently dysregulated in cancer and that has different consequences depending on cell lineage, allowing it to have oncogenic or tumor suppressive effects. One well-characterized context in which Notch is tumor suppressive is squamous cell carcinoma, as after mutations in TP53, mutations that disrupt Notch receptor activity are the most common mutations in cutaneous squamous cell carcinoma. However, Notch signaling also can be oncogen...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
In this issue of the International Journal of Radiation Oncology • Biology • Physics, Escande et al (1) report a phenomenal single-institution experience with interstitial 192Ir low-dose-rate or pulsed-dose-rate brachytherapy for squamous cell carcinoma of the glans penis. Their experience, which spans 45 years and involves more than 200 patients with a med ian follow-up of more than 10 years, indisputably establishes interstitial brachytherapy as an effective penile-sparing modality for squamous cell carcinoma of the glans.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
This study provides a valuable perspective on the timing of ILND following the rare diagnosis of penile cancer. In this retrospective evaluation of 84 patients without distant metastases who underwent ILND for squamous cell carcinoma of the penis from 1994 through 2014 the authors used Cox proportional hazard analyses to determine that men treated with early ILND (ie within 3 months of primary surgery) were less likely to have disease recurrence than those treated with late ILND (HR 0.48, 95% CI 0.21 –0.98).
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Adult Urology Source Type: research
Publication date: Available online 12 September 2017 Source:Actas Dermo-Sifiliográficas (English Edition) Author(s): J. Cañueto, C. Román-Curto The eighth edition of the staging manual of the American Joint Committee on Cancer incorporates important changes in the classification of skin cancers. Coming 40 years after the first edition, the latest manual preserves its specific system for Merkel cell carcinoma and takes into account recent publications on the prognosis of squamous cell carcinoma by defining a completely new T category for this neoplasm. Staging for squamous cell carcinoma considers head...
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Publication date: Available online 6 September 2017 Source:European Urology Supplements Author(s): Eva Compérat The majority of malignant tumors of the penis are squamous cell carcinomas. The origin is mostly the inner lining of the mucosa of the glans, the coronal sulcus, and the foreskin. Other tumors, such as basal cell carcinoma, are very rare. Numerous different subtypes have been reported and have been integrated into the new World Health Organization 2016 classification. These subtypes have distinct features and outcomes, and it is important to make the difference from a pathological point of view. During th...
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Publication date: Available online 6 September 2017 Source:European Urology Supplements Author(s): Andrea Necchi Penile squamous cell carcinoma (PSCC) is a very rare disease and its prognosis primarily depends on regional lymph node involvement. Although a cure can be obtained in patients with a low metastatic burden using surgery as standalone option, combined modality therapy is required for more advanced cases. In patients with multiple fixed or bulky inguinal lymph nodes, and in those with enlarged pelvic lymph nodes, chemotherapy is moderately effective, with an objective response rate of approximately 50% if a tripl...
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
To investigate predictive pathological factors for local recurrence (LR) after glansectomy for penile squamous cell carcinoma (SCC) and to develop a risk score for prediction of LR after glansectomy.
Source: Urologic Oncology: Seminars and Original Investigations - Category: Urology & Nephrology Authors: Tags: Original article Source Type: research
CONCLUSIONS: Perineural invasion, carcinoma in situ, positive definitive margins, and the presence of high-grade SCC predict LR following glansectomy. These factors can be used to stratify patients into low-, intermediate-, and high-risk groups for recurrence which may be used to tailor follow-up. PMID: 28882673 [PubMed - as supplied by publisher]
Source: Urologic Oncology - Category: Urology & Nephrology Authors: Tags: Urol Oncol Source Type: research
ConclusionDacomitinib was active and well tolerated in patients with advanced PSCC and may represent an option when combination chemotherapy cannot be administered. Mutations in downstream effectors of EGFR signaling in relation to dacomitinib activity deserve further studies.This article is protected by copyright. All rights reserved.
Source: BJU International - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
Corrigendum to “Predictors of Nodal Upstaging in Clinical Node Negative Patients With Penile Carcinoma: A National Cancer Database Analysis” [Urology 96 (2016) 29-34]
Source: Urology - Category: Urology & Nephrology Tags: Erratum Source Type: research
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