He lost his sight to cancer, but not his vision of a full life

When Tim Conners collected his wish from the Make-A-Wish Foundation in 2012 at the age of 18, he was blind from childhood leukemia that had spread to his optic nerve and craving inspiration to transcend his disability. A football player and wrestler who’d never been an outdoorsman, he asked to meet Erik Weihenmayer, the first blind person to climb the Seven Summits, the highest mountains on seven continents. Tim’s wish came true. He had 2½ terrifying but transformative days of outdoor adventures in Colorado with Erik, who lost his sight to a degenerative eye disorder at 13. Now Tim is training to climb Mount Kilimanjaro, the 19,000-foot peak in Tanzania in May, shortly after he graduates from Ithaca College. He’s already climbed four peaks in Colorado, including the 14,000-foot, snow- and loose-rock-covered Mount Sherman last summer. He’s trekked and rafted in the Grand Canyon. “In a lot of ways, losing my sight gave me my vision,” says Tim. Tim’s journey began on April 3, 2010, when he was diagnosed at Upstate Galisano Children’s Hospital in Syracuse, New York, near his home, with acute lymphoblastic leukemia (ALL), the most common pediatric cancer, with an overall 90 percent cure rate. Tim had T-cell ALL, a very aggressive subset that requires an intense chemotherapy regimen to achieve such a high cure rate. The intensive chemotherapy pushed Tim’s leukemia into remission, but the disease was back three m...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & Conditions Our Patients’ Stories acute lymphoblastic leukemia (ALL) Dana-Farber/Boston Children's Cancer and Blood Disorders Center stem cell transplant Source Type: news

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Authors: Gueudry J, Majo F, Delcampe A, Muraine M Abstract The corneal limbus is a privileged region on the border between two quite different microenvironments, where corneal epithelial stem cells, numerous melanocytes, and antigen-presenting cells are all concentrated within a richly vascularized and innervated stroma. This situation within the ocular surface confers on it the key functions of barrier, epithelial renewal and defense of the cornea. As an immunological crossroads and since the corneoscleral limbus is directly exposed to external insults such as caustic agents, ultraviolet radiation, microbial agent...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Abstract Cystoscopy and histology are the gold standards for detection of bladder cancer. However, these methods are highly subjective, expensive, and invasive. We have developed a non-invasive method for the diagnosis of bladder cancer by detecting telomerase activity in human urine. Telomerase substrate (TS) primer is elongated with repeating sequences of (TTAGGG)n in the presence of telomerase. The elongated primer can trigger hybridization chain reaction between two hairpins H1 and H2, result in the aggregation of AuNPs due to the hybridization between the tail sequence on H1 (or H2) and DNA-AuNPs probe, and a...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Almost all of us know someone with a disability. Four million veterans — more than one in five — are living with a disability that is the result of a disease or injury that occurred during active military service. And in a split second, an accident at work or while crossing the street could leave any one of us to contend with a changed physical or intellectual reality. In spite of this, a large body of evidence shows that people living with disabilities receive lower-quality care and less preventive care, and have a higher incidence of chronic conditions than people without disabilities. People with disabilitie...
Source: The Commonwealth Fund: Publications - Category: International Medicine & Public Health Authors: Source Type: research
This study primarily aimed to compare the validi...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
UR Medicine Orthopaedics and Thompson Health are partnering to deliver expansive orthopaedic and physical therapy services at a new office in Victor that opens April 29. The all-new, 21,000 square foot outpatient site will provide patients in Victor, Canandaigua and the Finger Lakes more convenient access to a wide range of orthopaedic services from Rochester-based specialists, as well as physical therapy and rehabilitation provided by Thompson Health experts.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news
We describe a case of a patient with severe intellectual disability and an open fracture of the distal lower limb. After fracture management and debridement of devitalized tissues, the resultant soft tissue defect was covered with a free gracilis flap. On postoperative day 7, the patient ripped out the newly transplanted flap. The flap was too traumatized for salvage, so a contralateral free gracilis muscle flap was used. The patient showed good aesthetic and functional outcomes at a 1-year follow-up. When planning the postoperative management of patients with psychiatric illness, less complex and more robust procedures ma...
Source: Archives of Plastic Surgery - Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research
Bacteria that are difficult or impossible to treat are being spread around the world, fueled by everything from flippant doctors to lax regulation, sewage, anti-vaxxers and international travel, experts warn.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This study aimed to investigate the potential of miRNA-181b (miR-181b) and its downstream target, ubiquitin C-terminal hydrolase-L1 (UCH-L1), to predict the severity of HIE. Full-term infants with perinatal asphyxia were recruited at birth and observed for the development of HIE, along with healthy controls. Levels of miR-181b and messenger UCH-L1 (mUCH-L1) in umbilical cord blood were determined using qRT-PCR. In total, 131 infants; 40 control, 50 perinatal asphyxia without HIE (PA) and 41 HIE, recruited across two separate cohorts (discovery and validation) were included in this study. Significant and consistent downregu...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
The article “The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection”, written by Motoi Azumi, Manabu Takeuchi, Youhei Koseki, Masaru Kumagai, Yoko Kobayashi, Masafumi Takatsuna, Aiko Yoshioka, Seiichi Yoshikawa, Tsutomu Miura, and Shuji Te rai, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 28 September 2018 without open access.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
ConclusionsAll three H3K27me modifier genes are individually associated with gastric cancer susceptibility with synergistic triad interaction. Not only two enzymes with the same function (KDM6A and KDM6B), but also those with opposite functions (EZH2 versus KDM6A or KDM6B) synergistically affect H3K27me consequences such as gastric cancer susceptibility.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
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