He lost his sight to cancer, but not his vision of a full life
When Tim Conners collected his wish from the Make-A-Wish Foundation in 2012 at the age of 18, he was blind from childhood leukemia that had spread to his optic nerve and craving inspiration to transcend his disability. A football player and wrestler who’d never been an outdoorsman, he asked to meet Erik Weihenmayer, the first blind person to climb the Seven Summits, the highest mountains on seven continents. Tim’s wish came true. He had 2½ terrifying but transformative days of outdoor adventures in Colorado with Erik, who lost his sight to a degenerative eye disorder at 13. Now Tim is training to climb Mount Kilimanjaro, the 19,000-foot peak in Tanzania in May, shortly after he graduates from Ithaca College. He’s already climbed four peaks in Colorado, including the 14,000-foot, snow- and loose-rock-covered Mount Sherman last summer. He’s trekked and rafted in the Grand Canyon. “In a lot of ways, losing my sight gave me my vision,” says Tim. Tim’s journey began on April 3, 2010, when he was diagnosed at Upstate Galisano Children’s Hospital in Syracuse, New York, near his home, with acute lymphoblastic leukemia (ALL), the most common pediatric cancer, with an overall 90 percent cure rate. Tim had T-cell ALL, a very aggressive subset that requires an intense chemotherapy regimen to achieve such a high cure rate. The intensive chemotherapy pushed Tim’s leukemia into remission, but the disease was back three m...
STOMACH cancer symptoms include a poor appetite, weight loss, and nausea. Treatment can include operations as well as changes to what you eat. Adapting your diet to include more of these foods could help to treat the condition.
This report warns that reluctance to talk honestly about death is preventing people with cancer from dying'well'. It calls for Governments across the UK to honour their commitments to ensuring Advance Care Planning is used as an important part of a person-centred health service, so that people approaching the end of their lives receive the best care possible and their wishes for death and dying are fulfilled
AN artificial intelligence revolution to prevent 22,000 cancer deaths by 2033 was being unveiled today. Theresa May is challenging the NHS to transform healthcare.
The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after>10 years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2018 Aug 01;264:158-164 Authors: Cainzos-Achirica M, Miedema MD, McEvoy JW, Cushman M, Dardari Z, Greenland P, Nasir K, Budoff MJ, Al-Mallah MH, Yeboah J, Blumenthal RS, Comin-Colet J, Blaha MJ Abstract BACKGROUND: The prognostic value of hsCRP in contemporary multi-ethnic populations is unclear, particularly in statin users. The aim of this study was to characterize the prognostic utility of hsCRP for atheroscleroti...
Abstract The molecular pathogenesis and classification of colorectal carcinoma are based on the traditional adenomaecarcinoma sequence, serrated polyp pathway, and microsatellite instability (MSI). The genetic basis for hereditary nonpolyposis colorectal cancer is the detection of mutations in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Genetic testing for Lynch syndrome includes MSI testing, methylator phenotype testing, BRAF mutation testing, and molecular testing for germline mutations in MMR genes. Molecular makers with predictive and prognostic implications include quantitative multigene reverse transcriptas...
Abstract MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provid...
CONCLUSIONS: Ring-shaped thread counter traction makes the most difficult duodenal ESD safer and easier without complications. PMID: 29764299 [PubMed - as supplied by publisher]
Bantounas et al. (Stem Cell Reports. 2018;10:766–779. https://doi.org/10.1016/j.stemcr.2018.01.008)
Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg) for adoptive transfer has potential to prevent organ rejection after kidney transplantation. However, the impact of dialysis and maintenance immunosuppression on the nTreg phenotype and peripheral survival is not well understood, but essential when assessing patient eligibility. The current study investigates regulatory T-cells in dialysis and kidney transplanted patients and the feasibility of generating a clinically useful nTreg product from these patients.
A 69-year-old man was referred to our department because of renal masses of the left kidney. The patient was diagnosed with a bladder carcinoma 10 months before in the context of macroscopic hematuria. The cancer had a partial squamous and papillary differentiation and was staged as G3pT1B with the infiltration of the superficial part of the bottom of the chorion. The patient underwent a transurethral resection of the bladder and had a course of intravesical injections of Bacillus Calmette-Guerin (BCG).
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