Opportunities for Therapeutic Intervention During Machine Perfusion

This article reviews the current status of MP with a focus on its role in organ pre-conditioning and therapeutic interventions prior to transplantation.Recent FindingsMP has allowed longer organ preservation compared to conventional static cold storage and allowed the use of organs that might otherwise have been discarded. Moreover, experimental studies have investigated the role of MP in reducing ischemia reperfusion injury of lungs, kidneys, and livers by applying mesenchymal stem cells (MSCs), anti-inflammatory agents, cytotopic anti-coagulants, and defatting cocktails.SummaryMP has opened a new era in the field of organ transplantation and tissue medication.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research