Potential pathogens in infertile male dromedary camels and their association with the spermiogram and clinical findings

AbstractThe role of five pathogens potentially implicated in the reproductive failure of 141 male dromedary camels was investigated. Breeding soundness examinations, which included semen analysis and testicular histopathology of the infertile male camels, were compared with seven camels of normal fertility. Antibodies againstChlamydia abortus (C. abortus) andToxoplasma gondii (T. gondii) were detected using the ELISA assay. Antibodies againstTrypanosoma evansi (T. evansi) were identified using the card agglutination test. The Rose Bengal plate agglutination test was used to detectBrucella species. Preputial swabs were cultured for the presence ofCampylobacter fetus (C. fetus). The incidence of positive titers ofC. abortus andT. evansi, and the incidence of positive culture ofC. fetus was found to be 13.5, 10.6, and 7.8%, respectively. T. evansi was more prevalent in younger (5 –7 years) than older (more than 7 years) camels (p = 0.02). Most of the semen characteristics were negatively affected in the camels exposed toC. abortus andT. evansi (p = 0.05).T. evansi,C. fetus, andC. abortus may have a role in lowering the reproductive efficiency of male dromedaries. However, further diagnostic techniques are recommended to confirm their association with lowered fertility in this species.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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ConclusionsThe quantity of TQBs available for transfer or cryopreservation can provide important predictors for pregnancy and live birth after the first embryo transfer cycle with a single blastocyst. This valuable information may assist with the future application of SBT.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
ConclusionLCT is rare, with a relative frequency (relative to GCT) of 1:23. Malignancy is found in 2.5%. LCT and GCT share a number of clinical features, e.g. bilaterality, history of undescended testis, and presenting age. TSS is safe in benign LCT. Surgery is the treatment of choice in malignant LCT.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
AbstractIntroductionEndometriosis symptoms are nonspecific and overlap with other gynecologic and gastrointestinal diseases, leading to long diagnostic delays. The burden of endometriosis has been documented; however, little is known about the impact of diagnostic delays on healthcare costs leading up to diagnoses. The purpose of this study was to examine the economic impact of diagnostic delays on pre-diagnosis healthcare utilization and costs among patients with endometriosis.MethodsThis was a retrospective database study of adult patients with a diagnosis of endometriosis from 1 January 2004 to 31 July 2016. Patients ha...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
AbstractIt is estimated that one in 100 men have azoospermia, the complete lack of sperm in the ejaculate. Currently,  ~ 20% of azoospermia cases remain idiopathic. Non-obstructive azoospermia (NOA) is mostly explained by congenital factors leading to spermatogenic failure, such as chromosome abnormalities. The knowledge of the monogenic causes of NOA is very limited. High genetic heterogeneity due to the compl exity of spermatogenesis and testicular function, lack of non-consanguineous familial cases and confirmatory studies challenge the field. The reported monogenic defects cause syndromic NOA phenotypes p...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
Conditions:   Infertility, Female, of Uterine Origin;   Endometrial Fibrosis Interventions:   Drug: CBD-bFGF;   Drug: Collagen/BMMNCs;   Drug: Estrogen Sponsors:   Yali Hu;   Chinese Academy of Sciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 16 January 2020Source: Saudi Journal of Biological SciencesAuthor(s): Salina Y. SaddickAbstractThe pathophysiology of polycystic ovary syndrome (PCOS) is confusing until today as it is a multifactorial endocrine disorder. It is presented with altered gonadotropin levels, bulky multi-follicular ovaries, infertility, and obesity. This complex pathophysiology is linked with insulin resistance and hyperandrogenism. Hyperandrogenemia significantly contributes towards cosmetic anomalies including hirsutism, acne, and alopecia in the PCOS women. The preexisting insulin resistance in women with P...
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Ureaplasma urealyticum (uu) is one of the most common agents of urogenital infections and is associated with complications such as infertility, spontaneous abortion and other sexually transmitted diseases. Here, a DNA sensor based on oligonucleotide target-specific gold nanoparticles (AuNPs) was developed, in which the dispersed and aggregated states of oligonucleotide-functionalised AuNPs were optimised for the colorimetric detection of a polymerase chain reaction (PCR) amplicon of U. urealyticum DNA. A non-cross-linking approach utilising a single Au-nanoprobe specific of the urease gene was utilised and the effect of a ...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Condition:   Endometriosis Related Infertility Intervention:   Procedure: Laparoscopic Endometriosis Surgery Sponsor:   Uludag University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy of current treatment options, a critical need exists to develop new and effective treatments for endometriosis. Niclosamide is an efficacious and FDA-approved drug for the treatment of helminthosis in humans that has been used for decades. We have reported that niclosamide reduces growth and progression of endometriosis-like lesions via targeting STAT3 and NFĸB signaling in a mouse model of endometriosis. To examine the effects of niclosamide on macrophag...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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