The safety of ovarian preservation in stage I endometrioid adenocarcinoma based on propensity score matching.

The safety of ovarian preservation in stage I endometrioid adenocarcinoma based on propensity score matching. Comb Chem High Throughput Screen. 2017 Apr 17;: Authors: Hou T, Wang Z, Sun Y, Liu C, Li J, Li Y Abstract Most patients with early stage endometrioid adenocarcinoma are treated with hysterectomy and bilateral oophorectomy to prevent ovarian metastasis. But this surgical menopause leads to some long-term sequelae for premenopausal women, especially for young women of childbearing age. This population-based study was to evaluate the safety of ovarian preservation in young women with stage I endometrioid adenocarcinoma.Patients of age 50 or younger than 50 with stage I endometrioid adenocarcinoma were explored from the Surveillance, Epidemiology, and End Results program database during 2004 to 2013. Propensity score matching was used to randomize the dataset and reduce the selection biases of doctors. Univariate analysis and multivariate cox proportional hazards model were utilized to estimate the safety of ovarian preservation. A total of 7183 patients were identified, and ovarian preservation was performed in 863 (12 %) patients. Compared with women treated with oophorectomy, patients with ovarian preservation significantly tend to be younger at diagnosis (P-value < 0.001) and more likely diagnosed as stage IA endometrioid adenocarcinoma, to have better differentiated tumor tissues and smaller tumors, as well as less li...
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research