Diagnostic performance of a novel dedicated breast PET scanner with C-shaped ring detectors

Conclusion: There was no significant difference in breast cancer detectability in this population. The C scanner demonstrated ∼1.6-fold larger maximum SUV than WB PET/CT.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research

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ConclusionNaF PET has relatively low sensitivity in detecting breast cancer. However, abnormal breast uptake on NaF PET requires further evaluation. F-18 fluoride uptake in the primary breast tumor does not seem to be correlated with axillary lymphadenopathy (metastasis potential), gross tumor calcification or metabolic activity of the tumor.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
ConclusionsWhole lumpectomy specimen micro-CT scanning is a promising technique for intraoperative margin assessment in BCS. Intraoperative quick feedback on the margin status could potentially lead to a reduction in the number of reoperations.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
1053Objectives: We compared 99mTc-sestamibi breast specific gamma imaging (BSGI) and fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to determine their clinical value in differentiating malignant breast lesions and discriminating between two malignant subtypes, invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS).Methods: A total of 224 patients who underwent preoperative DTP BSGI and 18F-FDG PET/CT between November 2010 and April 2014 were studied. All primary lesions were histopathologically confirmed as IDC or DCIS. BSGI and PET/CT results were compared wit...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer Posters Source Type: research
CONCLUSION: In DCIS and DCIS-Mi cases, significant correlations were found between increased FDG uptake and several histological and biological factors for poor prognosis (tumor size, Van Nuys Prognostic Index, and HER2). PMID: 27312540 [PubMed - as supplied by publisher]
Source: Breast Cancer - Category: Cancer & Oncology Authors: Tags: Breast Cancer Source Type: research
Conclusion:The Cbl metabolic pathway is upregulated within aggressive breast malignancies and can be biochemically targeted by a simple pulse-chase technique in vivo. The definitive mechanisms underpinning the up-regulated mitochondrial metabolism of Cbl within human breast tumors and the PC methodology remain to be elucidated. Further investigation of Cbl metabolism within benign and malignant breast tissue could potentially yield new molecular targets to detect and treat aggressive breast tumors.Citation Format: Collins DA. Cobalamin metabolism in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTR...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Conclusion PEM screening appears to have potential for breast cancer screening.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Aung Zaw Win, Carina Mari ApariciJournal of Clinical Imaging Science 2015 5(1):35-35Our patient was a 36-year-old female diagnosed with Grade II ER+/PR−/Her-2 − ductal carcinoma in situ (DCIS) in the left breast. She underwent left lumpectomy and received treatment with tamoxifen and radiotherapy. Three years later, she presented with multiple diffused skin nodules on the chest and upper left arm. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) exam showed widespread metastasis in the chest, upper left arm, left axillary lymph nodes, and left suprascapular muscle. FDG-PET/CT...
Source: Journal of Clinical Imaging Science - Category: Radiology Authors: Source Type: research
Abstract The purpose of this study is to determine the incidence of primary breast cancer (PBC) detected on (18) F-fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) in patients with a known diagnosis of non-mammary malignancies. A database search was performed to identify patients with non-mammary malignancies who had undergone staging with FDG PET–CT at a single institution between September 2005 and September 2011 and with the word “breast” reported in the PET–CT dictation. Additional breast imaging studies, clinical data, and the final histopatho...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Background: The aim of this study was to evaluate the significance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for predicting the underestimation of invasive breast cancer in cases of ductal carcinoma in situ (DCIS) at needle biopsy. Patients and Methods: Of 83 consecutive cases with diagnoses of DCIS at primary needle biopsy who underwent curative surgery between 2010 and 2013, the association between the maximum standardized uptake value (SUVmax) on FDG-PET/CT before excision and the underestimation of invasive breast cancer was examined. Results: There were 29 (34.9%) cases di...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
ConclusionsFDG‐PET/CT with whole‐body scanning demonstrated high sensitivity to invasive breast cancer, limited sensitivity to non‐invasive breast cancer, and high specificity for breast cancer. FDG‐PET/CT might be useful for differentiating tumour invasiveness. However, the good PPV but poor NPV do not allow the physician to discard the biopsy.
Source: Australasian Radiology - Category: Radiology Authors: Tags: Radiology—Original Article Source Type: research
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