Differential menopause- versus aging-induced changes in oxidative stress and circadian rhythm gene markers

Publication date: June 2017 Source:Mechanisms of Ageing and Development, Volume 164 Author(s): Oriol A. Rangel-Zuñiga, Cristina Cruz-Teno, Carmen Haro, Gracia M. Quintana-Navarro, Fernando Camara-Martos, Pablo Perez-Martinez, Antonio Garcia-Rios, Marta Garaulet, Manuel Tena-Sempere, Jose Lopez-Miranda, Francisco Perez-Jimenez, Antonio Camargo Menopause is characterized by the depletion of estrogen that has been proposed to cause oxidative stress. Circadian rhythm is an internal biological clock that controls physiological processes. It was analyzed the gene expression in peripheral blood mononuclear cells and the lipids and glucose levels in plasma of a subgroup of 17 pre-menopausal women, 19 men age-matched as control group for the pre-menopausal women, 20 post-menopausal women and 20 men age-matched as control group for the post-menopausal women; all groups were matched by body mass index. Our study showed a decrease in the expression of the oxidative stress-related gene GPX1, and an increase in the expression of SOD1 as consequence of menopause. In addition, we found that the circadian rhythm-related gene PER2 decreased as consequence of menopause. On the other hand, we observed a decrease in the expression of the oxidative stress-related gene GPX4 and an increase in the expression of CAT as a consequence of aging, independently of menopause. Our results suggest that the menopause-induced oxidative stress parallels a disruption in the circadian clock in wome...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research