Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review.

CONCLUSIONS: SSRI treatment can be associated with impaired semen quality. Potential underlying mechanisms include changes in sperm DNA integrity, activation of IDO and shifting tryptophan metabolism. Further studies of the effects of antidepressants on spermatogenesis might benefit from including investigation of changes in IDO activity during antidepressant administration. PMID: 24855891 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24855891?dopt=Abstract

Source: Acta Neuropsychiatrica - May 27, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research