β-Adrenergic Responsiveness in the Type 2 Diabetic Heart: Effects on Cardiac Reserve
This study aimed to determine the chronotopic and inotropic response of the type 2 diabetic heart to β-adrenergic stimulation.
Methods: Eight people with uncomplicated T2D and seven matched controls performed a dual-energy x-ray absorptiometry scan and V˙O2peak test. Plasma catecholamines were determined at rest and during peak exercise. On a second visit, HR and left ventricular contractility were assessed using echocardiography during supine rest, parasympathetic blockade (atropine), and during incremental β-adrenergic stimulation (dobutamine).
Results: V˙O2peak and HR reserve were lower in T2D (P
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Basic Sciences Source Type: research
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