Which Surgery Patients Don't Stop Taking Opioids When They Should?

The first time many patients in the United States take prescription opioid painkillers is following surgery. But not everyone puts away the pills: In a new study, researchers found that 6 percent of patients continued to use the drugs for at least three months after surgery. The researchers wanted to know more about why some people continue to use the drugs while others don’t, so they looked at the types of surgery people had. But it turned out that it didn’t matter whether someone had a major operation, such as bariatric surgery or a hysterectomy, or a minor procedure, such as varicose vein removal; there was no difference in how likely people were to continue to use opioids past the three-month mark. [Costly, Deadly, Complicated: These 7 Surgeries Take the Biggest Toll] However, the findings showed that the people who were more likely to continue to use the painkillers were those who smoked, drank alcohol, had certain mood disorders or had chronic pain. The findings suggest that whether a person continues to take prescription painkillers long after his or her surgery “is not due to surgical pain but addressable patient-level” risk factors, the researchers wrote in the study. In the study, a team of researchers led by Dr. Chad Brummett, an associate professor of pain management anesthesia at the University of Michigan Medical School, looked at data on more than 36,000 patients who received opioid painkillers after surgery in 2013 and 2014 but had not ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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We report about hirudotherapy in a patient with chronic complex regional pain syndrome (CRPS) in the right hand. CRPS is a multifactorial disease associated with disabling pain as well as sensory and motor deficits. The optimal therapeutic management is based on personalized multimodal treatment approaches; however, hirudotherapy has not been described in the available literature. To date, we have completed five medicinal leech treatments. Altogether, hirudotherapy led to rapid and substantial relief of symptoms, especially with respect to pain intensity ratings and skin temperature asymmetries. In Addition, the patient&rs...
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Conclusion: The decision-to-delivery interval was ≤ 15 min in most women, suggesting that optimised organisation ensures short decision-to-delivery interval independently of the anaesthetic technique performed. As general anaesthesia was associated with worse neonatal outcomes, our results support the early insertion of an epidural catheter whenever there is any potential concern that an emergency caesarean section may be required.
Source: Anaesthesia, Critical Care and Pain Medicine - Category: Anesthesiology Source Type: research
Publication date: June 2019Source: Anaesthesia &Intensive Care Medicine, Volume 20, Issue 6Author(s):
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: June 2019Source: Anaesthesia &Intensive Care Medicine, Volume 20, Issue 6Author(s):
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Materials Research and TechnologyAuthor(s): An Huang, Honglian Dai, Xiaopei Wu, Zheng Zhao, Yanzeng WuAbstractThe mesoporous hydroxyapatite (HAP) powder was synthesized by using the microemulsion (hexadecyltrimethyl ammonium bromide (CTAB)/cyclohexane/n-octyl alcohol) system. The optimal ratios of concentrations of CTAB, cyclohexane and n-octyl alcohol in the microemulsion on morphology of the HAP were studied. The effects of pHs and calcination temperatures on the phase composition of the HAP powder were discussed. The phase composition, morphology, mesoporo...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
ConclusionThe dosing for this indication is likely to be in the order of 100 million cells per infusion. Large numbers of cells thus need to be manufactured and using standard cell culture techniques would make it too expensive and labour intensive. A standard expansion protocol in flasks or cell factories is an open process, and therefore run in expensive clean rooms to avoid the risk of contamination. We have explored several state-of-the art-bioreactor systems, and various types of microcarriers in stirred tanks from different manufacturers. We have tested these systems to optimize the complete workflow of HepaStem cult...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionHere we show that in twelve clinical cases, the cartilage was observed successfully regenerating and covering the defect region in knees after the intra-articular injection with adipose-derived mesenchymal stem cells (MSCs), and the treatment highly improves the symptoms of osteoarthritis. Basically, the adipose-derived MSCs from the patients are cultured and expanded to a specific amount with the optimized stem cell culture medium, the HELENE MEDIUM. After that, the cultured MSCs are directly injected into the injured knee joints of patients. The cartilage has gradually regenerated and been monitored by MRI phot...
Source: Cytotherapy - Category: Cytology Source Type: research
Publication date: Available online 23 May 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Lea Boecker, Paul PauliAbstractStartle reflex potentiation versus startle attenuation to unpleasant versus pleasant stimuli likely reflect priming of the defensive versus appetitive motivational systems, respectively. This review summarizes and systemizes the literature on affective startle modulation related to psychopathologies with the aim to reveal underlying mechanisms across psychopathologies. We found evidence for psychopathologies characterized by increased startle potentiation to unpleasant stimuli (anxiety diso...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: Available online 23 May 2019Source: Neurochemistry InternationalAuthor(s): Sanjay Kumar, Ajeet Kumar Singh, Manjula VinayakAbstractReactive oxygen species (ROS) have a key role in different etiologies of pain. At sub-cellular level, mitochondria and plasma membranes have been identified as endogenous sources of ROS required for pain generation. NADPH oxidase (NOX) is the main contributor of membrane associated ROS generation. Out of 7 isozymes, NOX1, NOX2 and NOX4 are reported to be associated with nociceptive sensitization. Therefore, it has been hypothesized that specific inhibition of the NOX isozymes ...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
This study investigated the long-term consequences of post-weaning social isolation on behavior, VGF/BDNF/TrkB pathway and two isoforms of nitric oxide synthase (NOS) in the hippocampus and examined whether these effects were sex-specific. Male and female Sprague-Dawley rats were reared either in social isolation or social groups from postnatal day 21 for 9 weeks (n = 12–15/group and sex). Post-weaning social isolation induced impairments in sensorimotor gating and increased anxiety-like behavior in rats of both sexes. These behavioral alterations were accompanied by attenuated gene expression of VGF and TrkB rec...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
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