Lifestyle-Related Factors in the Self-Management of Chemotherapy-Induced Peripheral Neuropathy in Colorectal Cancer: A Systematic Review.

Conclusions. No strong conclusions can be drawn regarding the role of lifestyle-related factors in the management of CIPN in CRC patients. Certain dietary supplements and physical exercise may be beneficial for the management of CIPN, but further research is warranted. PMID: 28400846 [PubMed - in process]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Kentaro Nishida, Kazuya Takeuchi, Ayami Hosoda, Shohei Sugano, Eri Morisaki, Akihiro Ohishi, Kazuki NagasawaAbstractAimsOxaliplatin (l-OHP) is a key drug in therapeutic regimens for metastatic or advanced-stage colorectal cancer, but causes peripheral neuropathy as a dose-limiting adverse effect. It is reported that this peripheral neuropathy results from l-OHP accumulation in dorsal root ganglion (DRG) neurons, and that one of the transporters responsible for the accumulation in DRG neurons is organic cation transporter novel (OCTN) 1. Here, we ex...
Source: Life Sciences - Category: Biology Source Type: research
Introduction: mFOLFOX6 is a common first-line chemotherapy regimen for patients with unresectable, advanced or recurrent colorectal cancer (CRC). However, the long-term administration of oxaliplatin is associated with peripheral neuropathy (PN). Recently, we reported that 5-fluorouracil (5-FU)/leucovorin (LV) + panitumumab therapy after 6 fixed cycles of mFOLFOX6 + panitumumab therapy maintained efficacy with reduced incidence of PN, compared with continued treatment with mFOLFOX6 + panitumumab. Here, we report results from the final analysis of efficacy and safety endpoints (data cut-off: 31 Aug 2017), and from subgroup a...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Introduction: Oxaliplatin (OXA) is a cornerstone in the treatment of colorectal cancer (CRC). Retreatment with OXA is frequently considered as salvage treatment. OXA-induced neuropathy (OIN) is the most frequent and feared long-term side-effect.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Colorectal Cancer Intervention:   Device: VibrosSense Meter® Sponsor:   Lund University Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
I don’t mean that you will be struck down by simply stepping into a Dunkin’ Donuts. I mean that donuts and others things wheat and grains will substantially abbreviate y0ur life, or at least make your time on earth a lot more miserable. I’ve been accused of exaggeration to get the no-wheat, no-grain message through. But if you see what I see every day, I think that you would agree: The consumption of wheat and grains is entirely inappropriate for humans; we exchange near-term calories for deterioration of long-term health that takes numerous forms. And when you see lives completely turned around by banish...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle autoimmune bowel flora diabetes gluten-free grain-free grains Inflammation joint pain undoctored Source Type: blogs
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