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About New York: A Boy ’ s Life Is Lost to Sepsis. Thousands Are Saved in His Wake.

In 2012, Rory Staunton, 12, died from septic shock. Five years later, a study shows that fewer people are dying from the condition.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Sepsis Health Department (NYS) New York University Langone Medical Center Zucker, Howard A New York State Source Type: news

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Conclusion: Ext-PMX combined with RRT improved clinical outcomes in patients with nonsurgical septic shock and AKI.Blood Purif 2018;46:81 –89
Source: Blood Purification - Category: Hematology Source Type: research
Aim: The aim of this study was to investigate the effects of different vasopressors on the cerebral vasculature during experimental human endotoxemia and sepsis. We used the critical closing pressure (CrCP) as a measure of cerebral vascular tone. Methods: We performed a prospective pilot study, at the intensive care department (ICU) of a tertiary care university hospital in the Netherlands, in 40 healthy male subjects during experimental human endotoxemia (administration of bacterial lipopolysaccharide [LPS]) and in 10 patients with severe sepsis or septic shock. Subjects in the endotoxemia study were randomized to r...
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
Background: Sepsis and septic shock are common presentations of infective endocarditis (IE), but little is known about clinical characteristics in this group of patients, use of surgical treatment, and their associations with outcome. We sought to determine the influence of cardiac surgery (CS) on the outcome of patients with IE in different stages of sepsis severity. Methods: Two hundred ninety four patients with definite IE native or prosthetic valve IE admitted between 2000 and 2011. Prospective evaluation using multivariable logistic regression to evaluate clinical characteristics and outcomes (in-hospital and 1-y...
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
We recently published a comparison of two hydrocortisone dosage regimens in patients with septic shock. We compare the results conferred by the two regimens as a function of the response to cosyntropin stimulation test (CST). Patients with septic shock were treated by one of two hydrocortisone regimens: either a 50-mg intravenous bolus every 6 h during 7 days (200 mg group; n = 49), or a 100-mg initial bolus followed by a continuous infusion of 300 mg daily for 5 days (300 mg group; n = 50). Nonresponders was defined as a CST response of 9 μg/dL or less. Nonresponders had more severe septic shock, greate...
Source: Shock - Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research
Microcirculation is the motor of sepsis. In the present study, we investigated whether microcirculatory alterations occur before changes of systemic hemodynamics in a rat model of cecum ligation and puncture (CLP)-induced sepsis. We further investigated renal microcirculatory changes during sepsis and compared those with buccal microcirculation. Twelve male Sprague-Dawley rats were randomized into a sham control group (n = 6) and a CLP group (n = 6). Perfused microvessel density (PVD) and microvascular flow index (MFI) were evaluated using sidestream dark field (SDF) video microscopy at baseline—60, 120, 180,...
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research
Objectives: Our objectives were to determine first whether albumin prevents heparin-binding protein–induced increased endothelial cell permeability and renal cell inflammation and second, whether a plasma heparin-binding protein-to-albumin ratio predicts risk of acute kidney injury, fluid balance, and plasma cytokine levels in septic shock. Design: In vitro human endothelial and renal cell model and observation cohort of septic shock. Settings: Research laboratory and multicenter clinical trial (Vasopressin and Septic Shock Trial). Patients: Adult septic shock (norepinephrine dose> 5 μg/min for> 6...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
Conclusions: Secretoneurin provides early and potent prognostic information in septic patients with cardiovascular instability.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
This study sought to determine how well cases reported under state mandate align with discharge records in a statewide administrative database. Design: Observational cohort study. Setting: First 27 months of mandated sepsis reporting (April 1, 2014, to June 30, 2016). Patients: Hospitalizations with sepsis at New York State Article 28 acute care hospitals. Intervention: Sepsis regulations with mandated reporting. Measurements and Main Results: We compared cases reported to the New York State Department of Health Sepsis Clinical Database with discharge records in the Statewide Planning and Research Cooperativ...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Feature Articles Source Type: research
Conclusions: The New York Sepsis Severity Score accurately estimated the probability of hospital mortality in severe sepsis and septic shock patients. It performed well with respect to calibration and discrimination. This sepsis-specific model provides an accurate, comprehensive method for standardized mortality comparison of adult patients with severe sepsis and septic shock.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Feature Articles Source Type: research
In conclusion, high stone burden, long surgical time, positive stone culture, high pre-operative CRP and the presence of diabetes mellitus was could increase the risk of fever or SIRS after RIRS for kidney stone. The constructed nomograms could help clinicians in evaluating the risk for post-operative infectious complications.
Source: The Kaohsiung Journal of Medical Sciences - Category: Universities & Medical Training Source Type: research
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