Vancomycin Prophylaxis for Total Joint Arthroplasty: Incorrectly Dosed and Has a Higher Rate of Periprosthetic Infection Than Cefazolin.

Vancomycin Prophylaxis for Total Joint Arthroplasty: Incorrectly Dosed and Has a Higher Rate of Periprosthetic Infection Than Cefazolin. Clin Orthop Relat Res. 2017 Apr 11;: Authors: Kheir MM, Tan TL, Azboy I, Tan DD, Parvizi J Abstract BACKGROUND: In total joint arthroplasty (TJA), vancomycin is used as perioperative antibiotic prophylaxis in patients with penicillin allergy or in patients colonized with methicillin-resistant Staphylococcus aureus (MRSA). Although vancomycin dosing should be weight-based (15 mg/kg), not all surgeons are aware of this; a fixed 1-g dose is instead frequently administered. QUESTIONS/PURPOSES: (1) Is there a difference in the risk of periprosthetic joint infection (PJI) in patients receiving vancomycin or cefazolin prophylaxis after primary TJA? (2) What proportion of patients is adequately dosed with vancomycin? (3) Compared with actual fixed dosing, does weight-based dosing result in a greater proportion of patients staying above the recommended 15-mg/L level at the beginning and end of surgery? (4) Are patients overdosed with vancomycin at greater risk of developing nephrotoxicity and acute kidney injury? METHODS: A single-institution, retrospective study was performed on 1828 patients undergoing primary TJAs who received vancomycin prophylaxis between 2008 and 2014. During the same period, 5810 patients underwent primary TJA and received cefazolin monotherapy. A chart review was performed to obtain patien...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research

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CONCLUSIONS: Although consumption of a WPND was associated with a larger estimated GV in this pilot study, a larger study is necessary to conclude whether patients must fast longer than 2 hours after consumption of a WPND. PMID: 31630511 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Antagonists of the type 1 cysteinyl leukotriene receptor (CysLT1R) are widely used to treat asthma and allergic rhinitis, with variable response rates. Alveolar macrophages express UDP-specific P2Y6 receptors that can be blocked by off-target effects of CysLT1R antagonists. Sensitizing intranasal doses of an extract from the house dust mite Dermatophagoides farinae (Df) sharply increased the levels of UDP detected in bronchoalveolar lavage fluid of mice. Conditional deletion of P2Y6 receptors before sensitization exacerbated eosinophilic lung inflammation and type 2 cytokine production in response to subsequent Df challeng...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Authors: Liu S, Yang B, Yang P, Liu Z Abstract Formula-3 is a Chinese herbal medicine formula that was shown to inhibit food allergy in rats by stabilizing mast cells. But whether Formula-3 ameliorates food allergy through modulating the composition of intestinal microbiota remains to be explored. Here, we aimed to determine whether gut microbiota mediate the anti-food allergic effects of Formula-3. Mouse model of food allergy (FA) was induced by intragastrically administered with ovalbumin and cholera toxin for two weeks, then these mice were orally administrated daily with 1 ml PBS (0.1 mmol/L) or 1 ml Formula-3 ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Not washing hands after going to the toilet is behind the spread of a key strain of E. coli.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
In our series, Issues that Matter, we are focusing on the opioid crisis. According to the CDC, almost 400,000 Americans died from prescription and illicit opioid overdoses between 1999 and 2017. In 2017, more than 2.1 million Americans were addicted to opioids. This Saturday, the Drug Enforcement Administration is hosting National Prescription Drug Take Back Day, where you can turn in your unused and unwanted medications, no questions asked. Acting DEA Administrator Uttam Dhillon joins "CBS This Morning" to discuss the initiative.
Source: Health News: - Category: Consumer Health News Source Type: news
Low English proficiency puts patients with chronic conditions such as heart failure and COPD at much higher risk for returning to the hospital, new data show.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Hospital Medicine News Source Type: news
Publication date: Available online 22 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): O.V. Dement’eva, K.A. Naumova, S.K. Zhigletsova, M.V. Klykova, A.N. Somov, I.A. Dunaytsev, I.N. Senchikhin, V.V. Volkov, V.M. RudoyAbstractThe possibility of one-step creating of pH-sensitive mesostructured silica-based nanocontainers with exceptionally high payload using associates of two antiseptics (including hydrolyzable one) as templates is demonstrated.The effects of the template nature and the conditions of the sol-gel process on the porous structure of silica nanocontainers are studied and discussed. The...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Jeffrey A. SingerAreport in the October 21 issue ofJAMA Internal Medicine offers another reason for the Food and Drug Administration to reclassify the opioid overdose antidote naloxone over-the-counter. The study finds that despite a growing number of community pharmacies in the U.S. between 2009 and 2015, the overall numbers don ’t reflect the “churn” in the community pharmacy industry. The number of pharmacies increased from nearly 63,000 in 2009 to nearly 68,000 in 2015. But of the nearly 75,000 pharmacies in operation at any point during this time period, one in eight had closed by the end of 2015. It...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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