Molecular mechanisms for activation of mutant activin receptor-like kinase 2 in fibrodysplasia ossificans progressiva

Conclusion BMP type II receptor-dependent phosphorylation of ALK2 mutants in response to ligand binding is important for the activation of BMP signaling in FOP. Therefore, the use of anti-activin A compounds would be a novel treatment approach for FOP.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research