Combination pharmacoprophylaxis for post-ERCP pancreatitis: working toward an evidence base

Just because a medical intervention should theoretically work doesn ’t necessarily mean that it will. One of the most illustrative examples of this phenomenon is the effect of antiarrhythmic drugs on mortality after myocardial infarction (MI). Because arrhythmia is an important cause of death after acute MI, it was assumed that prophylactic antiarrhythmia therapy would improve clinical outcomes. Randomized trials, however, showed that antiarrhythmic agents were actually associated with increased mortality, thereby eliminating their use in this context.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research