Renal fibrosis: Pericytes activate complement in fibrosis

Nature Reviews Nephrology 13, 262 (2017). doi:10.1038/nrneph.2017.49 Author: Shimona Starling The complement pathway is activated during kidney fibrosis and may contribute to renal inflammation, but the underlying mechanisms are unclear. Using a mouse model of kidney injury, Xavier et al. show that platelet-derived growth factor receptor-β-positive pericytes (which are non-immune, interstitial cells) secrete
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research