Vinculin in cell-cell and cell-matrix adhesions.

Vinculin in cell-cell and cell-matrix adhesions.
Cell Mol Life Sci. 2017 Apr 11;:
Authors: Bays JL, DeMali KA
Abstract
Vinculin was identified as a component of focal adhesions and adherens junctions nearly 40 years ago. Since that time, remarkable progress has been made in understanding its activation, regulation and function. Here we discuss the current understanding of the roles of vinculin in cell-cell and cell-matrix adhesions. Emphasis is placed on the how vinculin is recruited, activated and regulated. We also highlight the recent understanding of how vinculin responds to and transmits force at integrin- and cadherin-containing adhesion complexes to the cytoskeleton. Furthermore, we discuss roles of vinculin in binding to and rearranging the actin cytoskeleton.
PMID: 28401269 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - April 11, 2017 Category: Cytology Authors: Bays JL, DeMali KA Tags: Cell Mol Life Sci Source Type: research