Smithfield Makes Move On Market For Pig-Human Transplants
Smithfield Foods, the world’s largest pork producer, has established a separate bioscience unit to expand its role in supplying pig parts for medical uses, with the ultimate goal of selling pig organs for transplantation into humans. Routine pig-human organ transplants are years away, but recent scientific advances are breaking down barriers that frustrated prior attempts to use pigs as a ready supply of replacement parts for sick or injured people, making it an attractive new market. “Our bread and butter has always been the bacon, sausage, fresh pork - very much a food-focused operation,” Courtney Stanton, vice president of Smithfield’s new bioscience unit, told Reuters in an exclusive interview. “We want to signal to the medical device and science communities that this is an area we’re focused on - that we’re not strictly packers,” she said. Smithfield, the $14 billion subsidiary of China’s WH Group (0288.HK), in its first move has joined a public-private tissue engineering consortium funded by an $80 million grant from the U.S. Department of Defense. Smithfield is the only pork producer, joining health-care companies including Abbott Laboratories (ABT.N), Medtronic (MDT.N) and United Therapeutics Corp (UTHR.O). Transplants are used for people diagnosed with organ failure and who have no other treatment options. Transplants from animals could help close a critical gap to help those in need. The United Network for Organ ...
CONCLUSIONMany ureteral inguinal hernias reported in the literature have been on renal transplant patients, while rarely on native kidneys. This case suggests no inguinal hernia repair is routine. Awareness of this anomaly is important, to avoid ureteral injury during herniorrhaphy.
Aim: Lateral incisional hernias, including parastomal-hernia, remain an important surgical challenge with the potential for significant morbidity. Current repairs generally rely on the use of mesh with attendant problems of infection (synthetics) and cost(biologics).
An 82-year-old man with a history of renal transplantation 14 years earlier presented with acute obstructive renal failure secondary to inguinal herniation of the urinary bladder complicated by ureteroneocystostomy entrapment. After percutaneous nephrostomy tube and endoscopic stent placement, the bladder was reduced and the hernia repaired with the use of a preperitoneal mesh. The postoperative course was uneventful and the renal function returned to normal. Inguinal herniation of the transplant ureter is a rare cause of hydronephrosis, but it has been described in the literature.
ConclusionsSG is technically feasible after LT and resulted in weight loss without adversely affecting graft function and immunosuppression. However, morbidity and mortality are high.
ConclusionsThe incidence of chronic inguinal pain is a common though underexposed complication after kidney transplantation. More awareness to prevent neuropathic pain seems indicated.
Abstract: Acute renal failure due to ureter compression after a mesh-plug inguinal repair in a kidney transplant recipient has not been previously reported to our knowledge. A 62-year-old man, who successfully underwent kidney transplantation from a deceased donor 6 years earlier, was admitted for elective repair of a direct inguinal hernia. The patient underwent an open mesh-plug repair of the inguinal hernia with placement of a plug in the preperitoneal space. We did not observe the transplanted ureter and bladder during dissection of the inguinal canal. Immediately after surgery, the patient became anuric, and a graft s...
We present the case of a 60-year-old male diagnosed with end stage renal disease due to polycystic kidney disease (urinary flow rate between 100-150mL/24h) in the study to enter renal transplantation waiting list. The patient complained of a right inguinoscrotal bulky mass, first noticed several years before. Physical examination suggested an irreducible inguinoscrotal hernia and surgical repair was offered before transplantation. PMID: 26677471 [PubMed - in process]
Authors: Valle GA, Kissane BE, de la Cruz-Muñoz N Abstract During the past several decades, the conventional management of peritoneal dialysis (PD) patients undergoing elective abdominal surgery required a transition to hemodialysis on a temporary basis. In recent years, that protocol has been challenged by various authors who successfully repaired hernias in such subjects without interruption of their PD modality. However, that new approach was reserved for abdominal wall procedures and was not used for intra-abdominal surgery. The rapid evolution of laparoscopic surgery and the development and refinement o...
Inguinal Herniation of a Transplant Ureter: Lessons Learned From a Case of "Water Over the Bridge". Exp Clin Transplant. 2015 Jun 25; Authors: Hakeem AR, Gopalakrishnan P, Dooldeniya MD, Irving HC, Ahmad N Abstract Inguinal herniation of the transplant ureter is rare, and there is a paucity of reports in the literature. Herniation is usually secondary to implanting a long redundant ureter and may be precipitated by its course over the spermatic cord. Most often, there is loss of the allograft owing to delayed presentation and chronic ureteric obstruction. Here, we report a case of inguinal h...
Conclusions For complex incisional hernias in KTRs, TAR is associated with low perioperative morbidity and durable repair.
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