Mutational and biochemical findings in adults with persistent hypophosphatasemia

ConclusionAdults with persistent hypophosphatasemia frequently harborALPL mutations and have elevated ALP substrates. These adults may fall within the spectrum of the adult form of hypophosphatasia. Clinicians should take note of persistent hypophosphatasemia in their patients and be cautious in prescribing bisphosphonates when present.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research