073 Th17 and Th22 polarization in ichthyosis blood correlates with disease severity and highlights its systemic nature

Ichthyoses are rare genetic disorders, lacking pathogenesis-based targeted treatments. Defined ichthyoses subtypes have been recently associated with Th17 activation in skin, similar to psoriasis. However, the underlying systemic T-cell polarization in ichthyosis blood is unknown. We thus characterized circulating T-cell subsets by flow cytometry in 50 patients with ichthyoses (congenital ichthyosiform erythroderma, lamellar ichthyosis, epidermolytic ichthyosis and Netherton syndrome/NS) vs. controls, atopic dermatitis (AD), and psoriasis patients.

Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: T. Czarnowicki, T. Huynh, Y. Itan, E. Ibler, G. Tran, J.G. Krueger, E. Guttman-Yassky, A.S. Paller Tags: Adaptive and Auto-Immunity Source Type: research